Literature DB >> 12430723

Modification of post-PKS tailoring steps through combinatorial biosynthesis.

Uwe Rix1, Carsten Fischer, Lily L Remsing, Jürgen Rohr.   

Abstract

This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases. ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.

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Year:  2002        PMID： 12430723     DOI： 10.1039/b103920m

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  66 in total

Review 1.  Protein engineering towards natural product synthesis and diversification.

Authors:  Angelica O Zabala; Ralph A Cacho; Yi Tang
Journal:  J Ind Microbiol Biotechnol       Date:  2011-10-18       Impact factor: 3.346

2.  Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII.

Authors:  Mohamed S Abdelfattah; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-08-25       Impact factor: 15.336

Review 3.  Combinatorial biosynthesis--potential and problems.

Authors:  Heinz G Floss
Journal:  J Biotechnol       Date:  2006-01-18       Impact factor: 3.307

4.  Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.

Authors:  Christopher T Calderone; Walter E Kowtoniuk; Neil L Kelleher; Christopher T Walsh; Pieter C Dorrestein
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-06       Impact factor: 11.205

5.  Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated.

Authors:  Tao Liu; Madan Kumar Kharel; Carsten Fischer; Andrew McCormick; Jürgen Rohr
Journal:  Chembiochem       Date:  2006-07       Impact factor: 3.164

6.  Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Authors:  Lily L Remsing; Ana M González; Mohammad Nur-e-Alam; M José Fernández-Lozano; Alfredo F Braña; Uwe Rix; Marcos A Oliveira; Carmen Méndez; José A Salas; Jürgen Rohr
Journal:  J Am Chem Soc       Date:  2003-05-14       Impact factor: 15.419

7.  Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Authors:  Mohamed S Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr
Journal:  J Nat Prod       Date:  2008-07-31       Impact factor: 4.050

8.  Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.

Authors:  Shwan Rachid; Ole Revermann; Christina Dauth; Uli Kazmaier; Rolf Müller
Journal:  J Biol Chem       Date:  2010-01-15       Impact factor: 5.157

9.  Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.

Authors:  Tyler Paz Korman; Yu-Hong Tan; Justin Wong; Ray Luo; Shiou-Chuan Tsai
Journal:  Biochemistry       Date:  2008-01-19       Impact factor: 3.162

10.  Detection, distribution, and organohalogen compound discovery implications of the reduced flavin adenine dinucleotide-dependent halogenase gene in major filamentous actinomycete taxonomic groups.

Authors:  Peng Gao; Ying Huang
Journal:  Appl Environ Microbiol       Date:  2009-05-15       Impact factor: 4.792
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