| Literature DB >> 23102024 |
Nidhi Tibrewal1, Pallab Pahari, Guojun Wang, Madan K Kharel, Caleb Morris, Theresa Downey, Yanpeng Hou, Tim S Bugni, Jürgen Rohr.
Abstract
GilOII has been unambiguously identified as the key enzyme performing the crucial C-C bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.Entities:
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Year: 2012 PMID： 23102024 PMCID： PMC3498853 DOI： 10.1021/ja3081154
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419