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Literature DB >> 17276041

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

Susanne Perkhofer¹, Harald Niederegger, Gerhard Blum, Wolfgang Burgstaller, Maximilian Ledochowski, Manfred P Dierich, Cornelia Lass-Flörl.

Abstract

This study examined the direct interaction of serotonin (5-hydroxytryptamine (5-HT)) with Aspergillus species. Accumulation of 5-HT in aspergilli was investigated by immunofluorescence staining and laser confocal scanning microscopy. The influence of 5-HT on fungal ergosterol content, cell membrane integrity, fungal growth and hyphal elongation was determined. 5-HT was localised in the cytoplasm of Aspergillus spp., as 5-HT fluorescent signals appeared after 30min at 4 degrees C and in the presence of inhibitors of oxidative phosphorylation. 5-HT treatment of Aspergillus spp. significantly affected ergosterol synthesis, fungal cell membrane integrity and hyphal elongation (P<0.05). 5-HT treatment for 4h resulted in a lag of re-growth (post-antifungal effect). In conclusion, our findings suggest that 5-HT affects hyphal growth and diminishes fungal cell membrane integrity.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17276041 PMCID： PMC3010239 DOI： 10.1016/j.ijantimicag.2006.12.003

Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283

27 in total

1. Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli.

Authors: Christoph Oberparleiter; Lydia Kaiserer; Hubertus Haas; Peter Ladurner; Manfred Andratsch; Florentine Marx
Journal: Antimicrob Agents Chemother Date: 2003-11 Impact factor: 5.191

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Journal: Br J Haematol Date: 2000-04 Impact factor: 6.998

7. Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro.

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Authors: K Hellstrand; S Hermodsson
Journal: Scand J Immunol Date: 1993-01 Impact factor: 3.487

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Authors: R Fischer; W E Timberlake
Journal: J Cell Biol Date: 1995-02 Impact factor: 10.539

6 in total

Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro.

1. Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli.

Review 2. Antifungal drugs and rational use of antifungals in treating invasive aspergillosis: the role of the hospital pharmacist.

Review 3. Secretable storage pools in platelets.

4. Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures.

Review 5. Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review.

6. Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia.

7. Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro.

Review 8. Epidemiology and pathogenesis of systemic fungal infections in the immunocompromised host.

9. Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes.

10. Aspergillus nidulans apsA (anucleate primary sterigmata) encodes a coiled-coil protein required for nuclear positioning and completion of asexual development.

Review 1. Innate immunity to Aspergillus species.

2. Interaction of platelets and anidulafungin against Aspergillus fumigatus.

3. Human platelets attenuate Aspergillus species via granule-dependent mechanisms.

4. Differential gene expression in Aspergillus fumigatus induced by human platelets in vitro.

5. Indications that the Antimycotic Drug Amphotericin B Enhances the Impact of Platelets on Aspergillus.

6. Dysregulation of Key Proteinases in Aspergillus fumigatus Induced by Blood Platelets.