Literature DB >> 18752432

Human platelets attenuate Aspergillus species via granule-dependent mechanisms.

Susanne Perkhofer1, Beate E Kehrel, Manfred P Dierich, J Peter Donnelly, Walter Nussbaumer, Johann Hofmann, Christof von Eiff, Cornelia Lass-Flörl.   

Abstract

Using laser scanning microscopy, we investigated whether platelets are capable of internalizing Aspergillus conidia and examined Aspergillus-platelet adherence. The influence of platelets on fungal growth was evaluated by assessing galactomannan (GM) release, hyphal elongation, and colony size. A secretion assay with [(3)H]-serotonin (5-hydroxytryptamine [5-HT]) was performed. Exposure to platelets resulted in significantly decreased GM release (p<.05), hyphal elongation (p<.001), colony size, pigmentation, and 5-HT release ( p<.05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects.

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Year:  2008        PMID： 18752432      PMCID： PMC2980866          DOI： 10.1086/591458

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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7.  Potential antifungal effects of human platelets against zygomycetes in vitro.

Authors:  Susanne Perkhofer; Barbara Kainzner; Beate E Kehrel; Manfred P Dierich; Walter Nussbaumer; Cornelia Lass-Flörl
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