| Literature DB >> 9313857 |
J A Beutler1, Y Kashman, L K Pannell, J H Cardellina, M R Alexander, M S Balaschak, T R Prather, R H Shoemaker, M R Boyd.
Abstract
A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.Entities:
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Year: 1997 PMID： 9313857 DOI： 10.1016/s0968-0896(97)00098-9
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641