PURPOSE OF REVIEW: The field of metabolomics is extending the principles of genomics into cellular and organism metabolism and driving a revolution in lipid biochemistry, physiology and nutrition. Lipids studied using metabolomic approaches - lipidomics - are an ideal subject for metabolomic measurements. RECENT FINDINGS: Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. Furthermore, by measuring changes in lipid concentrations, scientists are gaining a more detailed understanding of biochemistry and thus annotating genomes, but also understanding genetic polymorphisms and the postgenetic effects induced by drugs, foods and toxins. SUMMARY: Although in its infancy - there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids - the field of metabolomics is beginning to deliver on its promise to revolutionize lipid and metabolic disease research.
PURPOSE OF REVIEW: The field of metabolomics is extending the principles of genomics into cellular and organism metabolism and driving a revolution in lipid biochemistry, physiology and nutrition. Lipids studied using metabolomic approaches - lipidomics - are an ideal subject for metabolomic measurements. RECENT FINDINGS:Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. Furthermore, by measuring changes in lipid concentrations, scientists are gaining a more detailed understanding of biochemistry and thus annotating genomes, but also understanding genetic polymorphisms and the postgenetic effects induced by drugs, foods and toxins. SUMMARY: Although in its infancy - there are fewer than 200 total articles on lipidomics and metabolomics focusing on lipids - the field of metabolomics is beginning to deliver on its promise to revolutionize lipid and metabolic disease research.
Authors: Warwick B Dunn; David Broadhurst; Paul Begley; Eva Zelena; Sue Francis-McIntyre; Nadine Anderson; Marie Brown; Joshau D Knowles; Antony Halsall; John N Haselden; Andrew W Nicholls; Ian D Wilson; Douglas B Kell; Royston Goodacre Journal: Nat Protoc Date: 2011-06-30 Impact factor: 13.491
Authors: G P Holloway; C J Chou; J Lally; T Stellingwerff; A C Maher; O Gavrilova; M Haluzik; H Alkhateeb; M L Reitman; A Bonen Journal: Diabetologia Date: 2011-03-26 Impact factor: 10.122
Authors: Yulia Y Tyurina; Rosario M Domingues; Vladimir A Tyurin; Elisabete Maciel; Pedro Domingues; Andrew A Amoscato; Hülya Bayir; Valerian E Kagan Journal: Chem Phys Lipids Date: 2013-12-12 Impact factor: 3.329
Authors: Hyeyoung Lee; Hyun Joo An; Larry A Lerno; J Bruce German; Carlito B Lebrilla Journal: Int J Mass Spectrom Date: 2011-08-15 Impact factor: 1.986
Authors: Andrew N Lane; Teresa W-M Fan; Zhengzhi Xie; Hunter N B Moseley; Richard M Higashi Journal: Anal Chim Acta Date: 2009-08-27 Impact factor: 6.558
Authors: David S Wishart; Craig Knox; An Chi Guo; Roman Eisner; Nelson Young; Bijaya Gautam; David D Hau; Nick Psychogios; Edison Dong; Souhaila Bouatra; Rupasri Mandal; Igor Sinelnikov; Jianguo Xia; Leslie Jia; Joseph A Cruz; Emilia Lim; Constance A Sobsey; Savita Shrivastava; Paul Huang; Philip Liu; Lydia Fang; Jun Peng; Ryan Fradette; Dean Cheng; Dan Tzur; Melisa Clements; Avalyn Lewis; Andrea De Souza; Azaret Zuniga; Margot Dawe; Yeping Xiong; Derrick Clive; Russ Greiner; Alsu Nazyrova; Rustem Shaykhutdinov; Liang Li; Hans J Vogel; Ian Forsythe Journal: Nucleic Acids Res Date: 2008-10-25 Impact factor: 16.971