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Literature DB >> 16770418

Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror.

Wibool Piyawattanametha¹, Robert P J Barretto, Tony H Ko, Benjamin A Flusberg, Eric D Cocker, Hyejun Ra, Daesung Lee, Olav Solgaard, Mark J Schnitzer.

Abstract

Towards overcoming the size limitations of conventional two-photon fluorescence microscopy, we introduce two-photon imaging based on microelectromechanical systems (MEMS) scanners. Single crystalline silicon scanning mirrors that are 0.75 mm x 0.75 mm in size and driven in two dimensions by microfabricated vertical comb electrostatic actuators can provide optical deflection angles through a range of approximately16 degrees . Using such scanners we demonstrated two-photon microscopy and microendoscopy with fast-axis acquisition rates up to 3.52 kHz.

Entities: Chemical

Mesh：

Year: 2006 PMID： 16770418 PMCID： PMC2820363 DOI： 10.1364/ol.31.002018

Source DB: PubMed Journal: Opt Lett ISSN： 0146-9592 Impact factor: 3.776

11 in total

1. A miniature head-mounted two-photon microscope. high-resolution brain imaging in freely moving animals.

Authors: F Helmchen; M S Fee; D W Tank; W Denk
Journal: Neuron Date: 2001-09-27 Impact factor: 17.173

2. Electrostatic micromachine scanning mirror for optical coherence tomography.

Authors: J M Zara; S Yazdanfar; K D Rao; J A Izatt; S W Smith
Journal: Opt Lett Date: 2003-04-15 Impact factor: 3.776

3. In vivo multiphoton microscopy of deep brain tissue.

Authors: Michael J Levene; Daniel A Dombeck; Karl A Kasischke; Raymond P Molloy; Watt W Webb
Journal: J Neurophysiol Date: 2003-12-10 Impact factor: 2.714

4. Multiphoton endoscopy.

Authors: Juergen C Jung; Mark J Schnitzer
Journal: Opt Lett Date: 2003-06-01 Impact factor: 3.776

5. Two-photon fluorescence endoscopy with a micro-optic scanning head.

Authors: Damian Bird; Min Gu
Journal: Opt Lett Date: 2003-09-01 Impact factor: 3.776

6. Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography.

Authors: Xiumei Liu; Michael J Cobb; Yuchuan Chen; Michael B Kimmey; Xingde Li
Journal: Opt Lett Date: 2004-08-01 Impact factor: 3.776

7. In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope.

Authors: Benjamin A Flusberg; Juergen C Jung; Eric D Cocker; Erik P Anderson; Mark J Schnitzer
Journal: Opt Lett Date: 2005-09-01 Impact factor: 3.776

8. Endoscopic optical coherence tomography based on a microelectromechanical mirror.

Authors: Y Pan; H Xie; G K Fedder
Journal: Opt Lett Date: 2001-12-15 Impact factor: 3.776

9. Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror.

Authors: Ling Fu; Ankur Jain; Huikai Xie; Charles Cranfield; Min Gu
Journal: Opt Express Date: 2006-02-06 Impact factor: 3.894

10. Micromachined scanning confocal optical microscope.

Authors: D L Dickensheets; G S Kino
Journal: Opt Lett Date: 1996-05-15 Impact factor: 3.776

38 in total

1. Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue.

Authors: David R Rivera; Christopher M Brown; Dimitre G Ouzounov; Ina Pavlova; Demirhan Kobat; Watt W Webb; Chris Xu
Journal: Proc Natl Acad Sci U S A Date: 2011-10-17 Impact factor: 11.205

2. Fiber delivered probe for efficient CARS imaging of tissues.

Authors: Mihaela Balu; Gangjun Liu; Zhongping Chen; Bruce J Tromberg; Eric O Potma
Journal: Opt Express Date: 2010-02-01 Impact factor: 3.894

Review 3. Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide-field, full-color imaging.

Authors: Cameron M Lee; Christoph J Engelbrecht; Timothy D Soper; Fritjof Helmchen; Eric J Seibel
Journal: J Biophotonics Date: 2010-06 Impact factor: 3.207

4. Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.

Authors: Jonathan T C Liu; Michael J Mandella; Hyejun Ra; Larry K Wong; Olav Solgaard; Gordon S Kino; Wibool Piyawattanametha; Christopher H Contag; Thomas D Wang
Journal: Opt Lett Date: 2007-02-01 Impact factor: 3.776

Review 5. Next-generation optical technologies for illuminating genetically targeted brain circuits.

Authors: Karl Deisseroth; Guoping Feng; Ania K Majewska; Gero Miesenböck; Alice Ting; Mark J Schnitzer
Journal: J Neurosci Date: 2006-10-11 Impact factor: 6.167

Review 6. Future and advances in endoscopy.

Authors: Sakib F Elahi; Thomas D Wang
Journal: J Biophotonics Date: 2011-07-13 Impact factor: 3.207