| Literature DB >> 17215290 |
Binbin Deng1, Christine M O'Connor, Dean H Kedes, Z Hong Zhou.
Abstract
Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages.Entities:
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Year: 2007 PMID: 17215290 PMCID: PMC1866054 DOI: 10.1128/JVI.02254-06
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103