Literature DB >> 17215290

Direct visualization of the putative portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryoelectron tomography.

Binbin Deng1, Christine M O'Connor, Dean H Kedes, Z Hong Zhou.   

Abstract

Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages.

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Year:  2007        PMID: 17215290      PMCID: PMC1866054          DOI: 10.1128/JVI.02254-06

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  24 in total

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8.  Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus.

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Review 9.  Rhesus monkey rhadinovirus: a model for the study of KSHV.

Authors:  C M O'Connor; D H Kedes
Journal:  Curr Top Microbiol Immunol       Date:  2007       Impact factor: 4.291

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  19 in total

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8.  Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation.

Authors:  Binbin Deng; Christine M O'Connor; Dean H Kedes; Z Hong Zhou
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9.  Small capsid protein pORF65 is essential for assembly of Kaposi's sarcoma-associated herpesvirus capsids.

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10.  Four levels of hierarchical organization, including noncovalent chainmail, brace the mature tumor herpesvirus capsid against pressurization.

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