BACKGROUND: The efficacy of positron emission tomography with 18F fluoro-2-deoxy-D-glucose (FDG-PET) is obscure in evaluating viability or the extent of colorectal hepatic metastasis (CHM), down-staged by chemotherapy. PATIENTS AND METHODS: A retrospective lesion-by-lesion analysis was performed for seven consecutive patients, who had received rescue hepatectomy for initially unresectable CHM, in order to evaluate the correlation between results of imaging modalities and the corresponding pathology. RESULTS: The sensitivity and positive predictive value of the conventional modalities (CT and MRI) were 92% and 42%, respectively, while the sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET were 58%, 100%, 100% and 75% respectively. The sensitivity of FDG-PET was 100% in evaluating the viability of tumors >2 cm, however, this fell to 17% in tumors <2 cm. CONCLUSION: FDG-PET is effective in assessing the viability of tumors >2 cm, but not those <2 cm, in patients with CHM down-staged by chemotherapy.
BACKGROUND: The efficacy of positron emission tomography with 18F fluoro-2-deoxy-D-glucose (FDG-PET) is obscure in evaluating viability or the extent of colorectal hepatic metastasis (CHM), down-staged by chemotherapy. PATIENTS AND METHODS: A retrospective lesion-by-lesion analysis was performed for seven consecutive patients, who had received rescue hepatectomy for initially unresectable CHM, in order to evaluate the correlation between results of imaging modalities and the corresponding pathology. RESULTS: The sensitivity and positive predictive value of the conventional modalities (CT and MRI) were 92% and 42%, respectively, while the sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET were 58%, 100%, 100% and 75% respectively. The sensitivity of FDG-PET was 100% in evaluating the viability of tumors >2 cm, however, this fell to 17% in tumors <2 cm. CONCLUSION: FDG-PET is effective in assessing the viability of tumors >2 cm, but not those <2 cm, in patients with CHM down-staged by chemotherapy.
Authors: Laura L Travaini; Giuseppe Trifirò; Laura Ravasi; Lorenzo Monfardini; Paolo Della Vigna; Guido Bonomo; Antonio Chiappa; Andrew Mallia; Mahila Ferrari; Franco Orsi; Giovanni Paganelli Journal: Eur J Nucl Med Mol Imaging Date: 2008-03-13 Impact factor: 9.236
Authors: Marcus C B Tan; David C Linehan; William G Hawkins; Barry A Siegel; Steven M Strasberg Journal: J Gastrointest Surg Date: 2007-07-11 Impact factor: 3.452