Literature DB >> 17190474

Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.

Emily L Whitson1, S M V Damayanthi Mala, Charles A Veltri, Tim S Bugni, E Dilip de Silva, Chris M Ireland.   

Abstract

Two new sesquiterpene pyridine alkaloids, oppositines A (1) and B (2), have been isolated from the plant Pleurostylia opposita, collected in Sri Lanka. The compounds were isolated and purified by solvent/solvent partitioning, column chromatography, and HPLC. Their structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Oppositines A (1) and B (2) showed moderate cytotoxicity against HCT116 cell lines with EC50 values of 27 +/- 2 and 26 +/- 3 microM, respectively.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17190474      PMCID： PMC2533843          DOI： 10.1021/np060459s

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  12 in total

1.  New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line.

Authors:  J M Pérez-Victoria; B M Tincusi; I A Jiménez; I L Bazzocchi; M P Gupta; S Castanys; F Gamarro; A G Ravelo
Journal:  J Med Chem       Date:  1999-10-21       Impact factor: 7.446

2.  A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells.

Authors:  S E Kim; Y H Kim; J J Lee; Y C Kim
Journal:  J Nat Prod       Date:  1998-01       Impact factor: 4.050

3.  Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.

Authors:  M L Kennedy; F Cortés-Selva; J M Pérez-Victoria; I A Jiménez; A G González; O M Muñoz; F Gamarro; S Castanys; A G Ravelo
Journal:  J Med Chem       Date:  2001-12-20       Impact factor: 7.446

4.  Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.

Authors:  Y H Kuo; M L King; C F Chen; H Y Chen; C H Chen; K Chen; K H Lee
Journal:  J Nat Prod       Date:  1994-02       Impact factor: 4.050

5.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

6.  Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).

Authors:  A G González; B M Tincusi; I L Bazzocchi; H Tokuda; H Nishino; T Konoshima; I A Jiménez; A G Ravelo
Journal:  Bioorg Med Chem       Date:  2000-07       Impact factor: 3.641

7.  Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.

Authors:  H Duan; Y Takaishi; Y Imakura; Y Jia; D Li; L M Cosentino; K H Lee
Journal:  J Nat Prod       Date:  2000-03       Impact factor: 4.050

Review 8.  Celastraceae sesquiterpenoids: biological activity and synthesis.

Authors:  Alan C Spivey; Matthew Weston; Steven Woodhead
Journal:  Chem Soc Rev       Date:  2002-01       Impact factor: 54.564

9.  Insecticidal sesquiterpene pyridine alkaloids from Maytenus chiapensis.

Authors:  Marvin J Núñez; Ana Guadaño; Ignacio A Jiménez; Angel G Ravelo; Azucena González-Coloma; Isabel L Bazzocchi
Journal:  J Nat Prod       Date:  2004-01       Impact factor: 4.050

10.  Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

Authors:  Francisco Muñoz-Martínez; Peihua Lu; Fernando Cortés-Selva; José María Pérez-Victoria; Ignacio A Jiménez; Angel G Ravelo; Frances J Sharom; Francisco Gamarro; Santiago Castanys
Journal:  Cancer Res       Date:  2004-10-01       Impact factor: 12.701
View more
  1 in total

1.  Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection.

Authors:  Daniel Petinatti Pavarini; Denise Medeiros Selegato; Ian Castro-Gamboa; Luiz Vitor Silva do Sacramento; Maysa Furlan
Journal:  Molecules       Date:  2019-03-23       Impact factor: 4.411
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.