| Literature DB >> 10757718 |
H Duan1, Y Takaishi, Y Imakura, Y Jia, D Li, L M Cosentino, K H Lee.
Abstract
Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.Entities:
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Year: 2000 PMID： 10757718 DOI： 10.1021/np990281s
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050