Literature DB >> 9461657

A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells.

S E Kim1, Y H Kim, J J Lee, Y C Kim.   

Abstract

In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2,3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.

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Year:  1998        PMID： 9461657     DOI： 10.1021/np9702392

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mTOR Signaling Pathways.

Authors:  Ya-Yun Qian; Wen-Yuan Li; Yan Yan; Xue-Yu Zhao; Ting Yang; Chuan-Ci Fang; Jing-Jing Hou; Yan-Qing Liu
Journal:  Chin J Integr Med       Date:  2019-05-24       Impact factor: 1.978

2.  Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.

Authors:  Emily L Whitson; S M V Damayanthi Mala; Charles A Veltri; Tim S Bugni; E Dilip de Silva; Chris M Ireland
Journal:  J Nat Prod       Date:  2006-12       Impact factor: 4.050

3.  Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator.

Authors:  J M Pérez-Victoria; F J Pérez-Victoria; A Parodi-Talice; I A Jiménez; A G Ravelo; S Castanys; F Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

Review 4.  Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this?

Authors:  Qian Zhang; Yunjiang Feng; Derek Kennedy
Journal:  Cell Mol Life Sci       Date:  2016-09-12       Impact factor: 9.261

5.  Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells.

Authors:  Lin Yang; Yanqing Liu; Mei Wang; Yayun Qian; Xiaojun Dai; Yaodong Zhu; Jue Chen; Shiyu Guo; Tadashi Hisamitsu
Journal:  Oncol Lett       Date:  2016-09-29       Impact factor: 2.967

6.  Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65.

Authors:  Li Tong; Kamal D Moudgil
Journal:  Arthritis Res Ther       Date:  2007       Impact factor: 5.156

7.  A new insecticidal sesquiterpene ester from Celastrus angulatus.

Authors:  Shao-peng Wei; Zhi-qin Ji; Ji-wen Zhang
Journal:  Molecules       Date:  2009-03-30       Impact factor: 4.411
  7 in total

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