| Literature DB >> 10543882 |
J M Pérez-Victoria1, B M Tincusi, I A Jiménez, I L Bazzocchi, M P Gupta, S Castanys, F Gamarro, A G Ravelo.
Abstract
The effects produced by nine dihydro-beta-agarofuran sesquiterpenes isolated from Crossopetalum tonduzii (1-8) and Maytenus macrocarpa (9) (Celastraceae) on the reversion of the resistant phenotype on a multidrug-resistant Leishmania line and their binding to recombinant C-terminal nucleotide-binding domain of Leishmania P-glycoprotein-like transporter were studied. The structures of the new compounds (1-5) were elucidated by spectroscopic methods, including (1)H-(13)C heteronuclear correlation (HMQC), long-range correlation spectra with inversal detection (HMBC), ROESY experiments, and chemical correlations. The absolute configuration of one of them (1) was determined by CD studies. The structure-activity relationship is discussed.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10543882 DOI： 10.1021/jm991066b
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446