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Literature DB >> 17168571

Rings, radicals, and regeneration: the early years of a bioorganic laboratory.

Abstract

This Perspective provides an overview of the progress in two of the original programs in my research group focused on the biosynthesis of the antibiotics nisin, lacticin 481, fosfomycin, and bialaphos. The path from start-up funds to tenure and beyond offers insights into the opportunities realized and missed along the road.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17168571 PMCID： PMC2519235 DOI： 10.1021/jo0614240

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

103 in total

Review 1. Chemoselective ligation reactions with proteins, oligosaccharides and cells.

Authors: G A Lemieux; C R Bertozzi
Journal: Trends Biotechnol Date: 1998-12 Impact factor: 19.536

2. Ribosomal synthesis of dehydroalanine-containing peptides.

Authors: Florian P Seebeck; Jack W Szostak
Journal: J Am Chem Soc Date: 2006-06-07 Impact factor: 15.419

3. Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.

Authors: Ryan Woodyer; Huimin Zhao; Wilfred A van der Donk
Journal: FEBS J Date: 2005-08 Impact factor: 5.542

4. Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

Authors: Champak Chatterjee; Gregory C Patton; Lisa Cooper; Moushumi Paul; Wilfred A van der Donk
Journal: Chem Biol Date: 2006-10

5. Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.

Authors: Rick Rink; Anneke Kuipers; Esther de Boef; Kees J Leenhouts; Arnold J M Driessen; Gert N Moll; Oscar P Kuipers
Journal: Biochemistry Date: 2005-06-21 Impact factor: 3.162

6. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.

Authors: Y M Li; J C Milne; L L Madison; R Kolter; C T Walsh
Journal: Science Date: 1996-11-15 Impact factor: 47.728

7. Engineered biosynthesis of a complete macrolactone in a heterologous host.

Authors: C M Kao; L Katz; C Khosla
Journal: Science Date: 1994-07-22 Impact factor: 47.728

8. Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis.

Authors: Pinghua Liu; Mark P Mehn; Feng Yan; Zongbao Zhao; Lawrence Que; Hung-wen Liu
Journal: J Am Chem Soc Date: 2004-08-25 Impact factor: 15.419

9. Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates.

Authors: Danica P Galonić; Wilfred A Van Der Donk; David Y Gin
Journal: Chemistry Date: 2003-12-15 Impact factor: 5.236

10. Expressed protein ligation: a general method for protein engineering.

Authors: T W Muir; D Sondhi; P A Cole
Journal: Proc Natl Acad Sci U S A Date: 1998-06-09 Impact factor: 11.205

13 in total

1. Stereoselective additions of thiyl radicals to terminal ynamides.

Authors: Biplab Banerjee; Dmitry N Litvinov; Junghoon Kang; Jennifer D Bettale; Steven L Castle
Journal: Org Lett Date: 2010-06-04 Impact factor: 6.005

Review 2. Radical S-adenosylmethionine enzymes.

Authors: Joan B Broderick; Benjamin R Duffus; Kaitlin S Duschene; Eric M Shepard
Journal: Chem Rev Date: 2014-01-29 Impact factor: 60.622

3. Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Authors: Philip Olivares; Emily C Ulrich; Jonathan R Chekan; Wilfred A van der Donk; Satish K Nair
Journal: ACS Chem Biol Date: 2016-12-27 Impact factor: 5.100

4. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.

Authors: Seung Young Kim; Kou-San Ju; William W Metcalf; Bradley S Evans; Tomohisa Kuzuyama; Wilfred A van der Donk
Journal: Antimicrob Agents Chemother Date: 2012-05-21 Impact factor: 5.191

5. Significant increase of oxidase activity through the genetic incorporation of a tyrosine-histidine cross-link in a myoglobin model of heme-copper oxidase.

Authors: Xiaohong Liu; Yang Yu; Cheng Hu; Wei Zhang; Yi Lu; Jiangyun Wang
Journal: Angew Chem Int Ed Engl Date: 2012-03-12 Impact factor: 15.336

10. In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis.

Authors: Jin-Hee Lee; Bradley S Evans; Gongyong Li; Neil L Kelleher; Wilfred A van der Donk
Journal: Biochemistry Date: 2009-06-16 Impact factor: 3.162

Rings, radicals, and regeneration: the early years of a bioorganic laboratory.

Review 1. Chemoselective ligation reactions with proteins, oligosaccharides and cells.

2. Ribosomal synthesis of dehydroalanine-containing peptides.

3. Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.

4. Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

5. Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.

6. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.

7. Engineered biosynthesis of a complete macrolactone in a heterologous host.

8. Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis.

9. Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates.

10. Expressed protein ligation: a general method for protein engineering.

1. Stereoselective additions of thiyl radicals to terminal ynamides.

Review 2. Radical S-adenosylmethionine enzymes.

3. Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

4. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.

5. Significant increase of oxidase activity through the genetic incorporation of a tyrosine-histidine cross-link in a myoglobin model of heme-copper oxidase.

Review 6. Anaerobic functionalization of unactivated C-H bonds.

7. Mechanistic and functional versatility of radical SAM enzymes.

Review 8. Biosynthesis of phosphonic and phosphinic acid natural products.

Review 9. Vitamin B₁₂ in the spotlight again.

10. In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis.

Review 1. Chemoselective ligation reactions with proteins, oligosaccharides and cells.

Review 2. Radical S-adenosylmethionine enzymes.

Review 6. Anaerobic functionalization of unactivated C-H bonds.

Review 8. Biosynthesis of phosphonic and phosphinic acid natural products.

Review 9. Vitamin B12 in the spotlight again.

Review 9. Vitamin B₁₂ in the spotlight again.