| Literature DB >> 17142046 |
Robert Musiol1, Josef Jampilek, Katarina Kralova, Des R Richardson, Danuta Kalinowski, Barbara Podeszwa, Jacek Finster, Halina Niedbala, Anna Palka, Jaroslaw Polanski.
Abstract
The lack of the wide spectrum of biological data is an important obstacle preventing the efficient molecular design. Quinoline derivatives are known to exhibit a variety of biological effects. In the current publication, we tested a series of novel quinoline analogues for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Moreover, antiproliferative activity was measured using SK-N-MC neuroepithelioma cell line. We described the structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds. We also measured the lipophilicity of the novel compounds by means of the RP-HPLC and illustrate the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs.Entities:
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Year: 2006 PMID： 17142046 DOI： 10.1016/j.bmc.2006.11.020
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641