| Literature DB >> 17125221 |
Taro Amagata1, Brandon I Morinaka, Akiko Amagata, Karen Tenney, Frederick A Valeriote, Emil Lobkovsky, Jon Clardy, Phillip Crews.
Abstract
Two novel cyclic depsipeptides, guangomides A (1) and B (2), together with a new destruxin derivative (3) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus. The new structures were elucidated on the basis of analysis of extensive 1D and 2D NMR data sets, and the absolute configurations of 2S, 9S, 13S, 19S, 24R, 28R of 1 were determined on the basis of the combined X-ray and Marfey's method structure analysis. Identical absolute configurations were assumed for 2. The cytotoxicity of the extract was found to be due to brefeldin A, while 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.Entities:
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Year: 2006 PMID： 17125221 PMCID： PMC3014288 DOI： 10.1021/np060178k
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050