Literature DB >> 11142846

N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium.

M Cueto1, P R Jensen, W Fenical.   

Abstract

N-Methylsansalvamide (1), a new cyclic depsipeptide, was isolated from extracts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxicity in the NCI human tumor cell line screen (GI50 8.3 microM). The structure of 1 was determined by combined spectral and chemical methods.

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Year:  2000        PMID： 11142846     DOI： 10.1016/s0031-9422(00)00280-6

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  12 in total

1.  Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives.

Authors:  Robert P Sellers; Leslie D Alexander; Victoria A Johnson; Chun-Chieh Lin; Jeremiah Savage; Ricardo Corral; Jason Moss; Tim S Slugocki; Erinprit K Singh; Melinda R Davis; Suchitra Ravula; Jamie E Spicer; Jenna L Oelrich; Andrea Thornquist; Chung-Mao Pan; Shelli R McAlpine
Journal:  Bioorg Med Chem       Date:  2010-07-22       Impact factor: 3.641

2.  Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90.

Authors:  Joseph B Kunicki; Mark N Petersen; Leslie D Alexander; Veronica C Ardi; Jeanette R McConnell; Shelli R McAlpine
Journal:  Bioorg Med Chem Lett       Date:  2011-06-25       Impact factor: 2.823

3.  Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.

Authors:  Robert C Vasko; Rodrigo A Rodriguez; Christian N Cunningham; Veronica C Ardi; David A Agard; Shelli R McAlpine
Journal:  ACS Med Chem Lett       Date:  2010-01-01       Impact factor: 4.345

4.  A chemical study of cyclic depsipeptides produced by a sponge-derived fungus.

Authors:  Taro Amagata; Brandon I Morinaka; Akiko Amagata; Karen Tenney; Frederick A Valeriote; Emil Lobkovsky; Jon Clardy; Phillip Crews
Journal:  J Nat Prod       Date:  2006-11       Impact factor: 4.050

5.  A comprehensive study of Sansalvamide A derivatives: The structure-activity relationships of 78 derivatives in two pancreatic cancer cell lines.

Authors:  Po-Shen Pan; Robert C Vasko; Stephanie A Lapera; Victoria A Johnson; Robert P Sellers; Chun-Chieh Lin; Chung-Mao Pan; Melinda R Davis; Veronica C Ardi; Shelli R McAlpine
Journal:  Bioorg Med Chem       Date:  2009-07-15       Impact factor: 3.641

6.  Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide in Fusarium solani.

Authors:  Patricia Romans-Fuertes; Teis Esben Sondergaard; Manuela Ilse Helga Sandmann; Rasmus Dam Wollenberg; Kristian Fog Nielsen; Frederik T Hansen; Henriette Giese; Ditlev Egeskov Brodersen; Jens Laurids Sørensen
Journal:  Curr Genet       Date:  2016-03-02       Impact factor: 3.886

7.  Toward the synthesis and biological screening of a cyclotetrapeptide from marine bacteria.

Authors:  Rajiv Dahiya; Hemendra Gautam
Journal:  Mar Drugs       Date:  2010-12-30       Impact factor: 5.118

8.  Low water activity induces the production of bioactive metabolites in halophilic and halotolerant fungi.

Authors:  Kristina Sepcic; Polona Zalar; Nina Gunde-Cimerman
Journal:  Mar Drugs       Date:  2010-12-27       Impact factor: 5.118

Review 9.  Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential.

Authors:  Shivankar Agrawal; Debabrata Acharya; Alok Adholeya; Colin J Barrow; Sunil K Deshmukh
Journal:  Front Pharmacol       Date:  2017-11-21       Impact factor: 5.810

10.  A tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation tools.

Authors:  Joydeep Mukherjee; Lyndon E Llewellyn; Elizabeth A Evans-Illidge
Journal:  Mar Drugs       Date:  2008-10-13       Impact factor: 5.118
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