A new tripeptide, pre-sclerotiotide F (3), was isolated from a marine sediment-derived fungus, Aspergillus insulicola, along with five known compounds, one of which was new at the time of isolation, scerotiotide F (4). The absolute configuration elucidation of the new compound was determined using a combination of NMR, HR-ESI-MS, and optical rotation analyses. Cytotoxicities were measured in vitro against selected cancer cells. The effects of pre-sclerotiotide F (3) and sclerotiotide F (4) on LPS-induced NF-κB and iNOS expression were also measured.
A new tripeptide, pre-n class="Chemical">sclerotiotide F (3), was isolated from a marine sediment-derived fungus, Aspergillus insulicola, along with five known compounds, one of which was new at the time of isolation, scerotiotide F (4). The absolute configuration elucidation of the new compound was determined using a combination of NMR, HR-ESI-MS, and optical rotation analyses. Cytotoxicities were measured in vitro against selected cancer cells. The effects of pre-sclerotiotide F (3) and sclerotiotide F (4) on LPS-induced NF-κB and iNOS expression were also measured.
Authors: Quan-Xiang Wu; Mitchell S Crews; Marija Draskovic; Johann Sohn; Tyler A Johnson; Karen Tenney; Frederick A Valeriote; Xiao-Jun Yao; Leonard F Bjeldanes; Phillip Crews Journal: Org Lett Date: 2010-10-15 Impact factor: 6.005
Authors: Claudia M Boot; Nadine C Gassner; Jennifer E Compton; Karen Tenney; Craig M Tamble; R Scott Lokey; Theodore R Holman; Phillip Crews Journal: J Nat Prod Date: 2007-10-12 Impact factor: 4.050