Literature DB >> 1711512

Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive protein production.

A W Taylor1, R F Mortensen.   

Abstract

Alpha-2-macroglobulin (alpha 2-M), a serum protease inhibitor that also binds cytokines, neutralized the inhibitory effect exerted by transforming growth factor-beta (TGF-beta) on IL-6-induced C-reactive protein (CRP) production by the human hepatoma cell line PLC/PRF/5. alpha 2-M was found to bind noncovalently with TGF-beta to form a complex that, upon acidification, released TGF-beta inhibitory activity as detected by IL-6-induced CRP production. Although alpha 2-M also binds IL-6, it did not alter IL-6-induced CRP production by the hepatoma cells. The interaction between alpha 2-M and TGF-beta may influence the production of acute-phase proteins by liver hepatocytes.

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Year:  1991        PMID： 1711512     DOI： 10.1007/bf00917910

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  31 in total

1.  Differential inhibition of transforming growth factor beta 1 and beta 2 activity by alpha 2-macroglobulin.

Authors:  D Danielpour; M B Sporn
Journal:  J Biol Chem       Date:  1990-04-25       Impact factor: 5.157

2.  Model of alpha 2-macroglobulin structure and function.

Authors:  S R Feldman; S L Gonias; S V Pizzo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

3.  Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

Authors:  M D O'Connor-McCourt; L M Wakefield
Journal:  J Biol Chem       Date:  1987-10-15       Impact factor: 5.157

4.  Inflammatory and immunomodulatory roles of TGF-beta.

Authors:  S M Wahl; N McCartney-Francis; S E Mergenhagen
Journal:  Immunol Today       Date:  1989-08

5.  Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines.

Authors:  M K Ganapathi; L T May; D Schultz; A Brabenec; J Weinstein; P B Sehgal; I Kushner
Journal:  Biochem Biophys Res Commun       Date:  1988-11-30       Impact factor: 3.575

6.  Stimulation of murine hemopoietic colony formation by human IL-6.

Authors:  G G Wong; J S Witek-Giannotti; P A Temple; R Kriz; C Ferenz; R M Hewick; S C Clark; K Ikebuchi; M Ogawa
Journal:  J Immunol       Date:  1988-05-01       Impact factor: 5.422

Review 7.  Transforming growth factor beta.

Authors:  A B Roberts; M B Sporn
Journal:  Adv Cancer Res       Date:  1988       Impact factor: 6.242

8.  Characteristics of the macrophage uptake of proteinase-alpha-macroglobulin complexes.

Authors:  M T Debanne; R Bell; J Dolovich
Journal:  Biochim Biophys Acta       Date:  1976-04-23

9.  Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6.

Authors:  U Ganter; R Arcone; C Toniatti; G Morrone; G Ciliberto
Journal:  EMBO J       Date:  1989-12-01       Impact factor: 11.598

10.  Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro.

Authors:  G J Darlington; D R Wilson; L B Lachman
Journal:  J Cell Biol       Date:  1986-09       Impact factor: 10.539
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  1 in total

1.  Transcriptional reprogramming in nonhuman primate (rhesus macaque) tuberculosis granulomas.

Authors:  Smriti Mehra; Bapi Pahar; Noton K Dutta; Cecily N Conerly; Kathrine Philippi-Falkenstein; Xavier Alvarez; Deepak Kaushal
Journal:  PLoS One       Date:  2010-08-31       Impact factor: 3.240
  1 in total

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