Literature DB >> 2412223

Model of alpha 2-macroglobulin structure and function.

S R Feldman, S L Gonias, S V Pizzo.   

Abstract

A model of alpha 2-macroglobulin is presented that is compatible with previous structural, functional, and phylogenetic studies of the protein. The model of the molecule resembles a hollow cylinder and is comprised of two identical functional halves with three C2 axes of symmetry and no mirror planes. The "trap mechanism" of this proteinase inhibitor is effected by slight movement of two trap arms per "half-molecule." Evidence for this model is obtained from the study of the structure and proteinase binding of the molecule. By using this model, predictions are made concerning proteinase binding ratios, receptor recognition, and "slow-to-fast" conformational change of the molecule.

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Year:  1985        PMID： 2412223      PMCID： PMC390619          DOI： 10.1073/pnas.82.17.5700

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Uptake of proteinase-alpha-macroglobulin complexes by macrophages.

Authors:  M T Debanne; R Bell; J Dolovich
Journal:  Biochim Biophys Acta       Date:  1975-12-05

Review 2.  Immunoglobulin structure and effector functions.

Authors:  J L Winkelhake
Journal:  Immunochemistry       Date:  1978-09

3.  A thiol-ester in alpha 2-macroglobulin cleaved during proteinase complex formation.

Authors:  L Sottrup-Jensen; T E Petersen; S Magnusson
Journal:  FEBS Lett       Date:  1980-12-01       Impact factor: 4.124

4.  A monoclonal antibody to a neo-antigen on alpha 2-macroglobulin complexes inhibits receptor-mediated endocytosis.

Authors:  P Marynen; F Van Leuven; J J Cassiman; H Van den Berghe
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

5.  Characterization of alkylamine-sensitive site in alpha 2-macroglobulin.

Authors:  R P Swenson; J B Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

6.  The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule.

Authors:  A J Barrett; M A Brown; C A Sayers
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

7.  Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution.

Authors:  H Muirhead; J M Cox; L Mazzarella; M F Perutz
Journal:  J Mol Biol       Date:  1967-08-28       Impact factor: 5.469

8.  Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.

Authors:  M J Imber; S V Pizzo
Journal:  J Biol Chem       Date:  1981-08-10       Impact factor: 5.157

9.  Localization of the two protease binding sites in human alpha 2-macroglobulin.

Authors:  F Pochon; V Favaudon; M Tourbez-Perrin; J Bieth
Journal:  J Biol Chem       Date:  1981-01-25       Impact factor: 5.157

10.  Further characterization of the covalent linking reaction of alpha 2-macroglobulin.

Authors:  G S Salvesen; C A Sayers; A J Barrett
Journal:  Biochem J       Date:  1981-05-01       Impact factor: 3.857
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  29 in total

1.  Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.

Authors:  Uma Kant Misra; Salvatore Vincent Pizzo
Journal:  J Biol Chem       Date:  2015-02-26       Impact factor: 5.157

2.  Structural studies of human alpha 2-macroglobulin: concordance between projected views obtained by negative-stain and cryoelectron microscopy.

Authors:  J K Stoops; J P Schroeter; J P Bretaudiere; N H Olson; T S Baker; D K Strickland
Journal:  J Struct Biol       Date:  1991-04       Impact factor: 2.867

3.  Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography.

Authors:  S L Gonias; P A Roche; S V Pizzo
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

4.  Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin.

Authors:  C Crawford
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

5.  The conformational changes of alpha 2-macroglobulin induced by methylamine or trypsin. Characterization by extrinsic and intrinsic spectroscopic probes.

Authors:  L J Larsson; P Lindahl; C Hallén-Sandgren; I Björk
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

6.  Novel complex formed between a nonproteolytic cell wall protein of group A streptococci and alpha 2-macroglobulin.

Authors:  G S Chhatwal; G Albohn; H Blobel
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490

7.  Structure of native alpha 2-macroglobulin and its transformation to the protease bound form.

Authors:  J P Bretaudiere; J Tapon-Bretaudiere; J K Stoops
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

8.  Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.

Authors:  Irene Garcia-Ferrer; Pedro Arêde; Josué Gómez-Blanco; Daniel Luque; Stephane Duquerroy; José R Castón; Theodoros Goulas; F Xavier Gomis-Rüth
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

9.  ATP-Dependent inactivation and sequestration of ornithine decarboxylase by the 26S proteasome are prerequisites for degradation.

Authors:  Y Murakami; S Matsufuji; S I Hayashi; N Tanahashi; K Tanaka
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

10.  Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva.

Authors:  Xiuli Sun; Erdjan Salih; Frank G Oppenheim; Eva J Helmerhorst
Journal:  Proteomics Clin Appl       Date:  2009-07-01       Impact factor: 3.494
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