| Literature DB >> 17095233 |
Harunobu Mukaiyama1, Toshihiro Nishimura, Satoko Kobayashi, Tomonaga Ozawa, Noboru Kamada, Yoshimitsu Komatsu, Shinji Kikuchi, Hideki Oonota, Hiroshi Kusama.
Abstract
We synthesized and evaluated a series of C-5 substituted imidazo[1,5-a]pyrazine derivatives to identify potent c-Src inhibitors as potential therapeutic agents for acute ischemic stroke. Among these compounds, compound 14c.HCl demonstrated remarkable central nervous system (CNS) penetration and significant neuroprotective efficacy in vivo in rat models.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17095233 DOI： 10.1016/j.bmc.2006.10.041
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641