Literature DB >> 17074820

The routinisation of genomics and genetics: implications for ethical practices.

M W Foster1, C D M Royal, R R Sharp.   

Abstract

Among bioethicists and members of the public, genetics is often regarded as unique in its ethical challenges. As medical researchers and clinicians increasingly combine genetic information with a range of non-genetic information in the study and clinical management of patients with common diseases, the unique ethical challenges attributed to genetics must be re-examined. A process of genetic routinisation that will have implications for research and clinical ethics, as well as for public conceptions of genetic information, is constituted by the emergence of new forms of genetic medicine, in which genetic information is interpreted in a multifactorial frame of reference. Although the integration of genetics in medical research and treatment may be a helpful corrective to the mistaken assumptions of genetic essentialism or determinism, the routinisation of genetics may have unintended consequences for the protection of genetic information, perceptions of non-genetic information and the loss of genetic research as a laboratory for exploring issues in research and clinical ethics. Consequently, new ethical challenges are presented by the increasing routinisation of genetic information in both biomedical and public spheres.

Entities:  

Mesh:

Year:  2006        PMID: 17074820      PMCID: PMC2563298          DOI: 10.1136/jme.2005.013532

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  20 in total

1.  Genetic research and culturally specific risks: one size does not fit all.

Authors:  M W Foster; R R Sharp
Journal:  Trends Genet       Date:  2000-02       Impact factor: 11.639

2.  Protecting the privacy of family members in survey and pedigree research.

Authors:  J Botkin
Journal:  JAMA       Date:  2001-01-10       Impact factor: 56.272

3.  Genetic exceptionalism vs. paradigm shift: lessons from HIV.

Authors:  L F Ross
Journal:  J Law Med Ethics       Date:  2001       Impact factor: 1.718

Review 4.  What is 'public opinion' about genetics?

Authors:  C Condit
Journal:  Nat Rev Genet       Date:  2001-10       Impact factor: 53.242

5.  "Genetic exceptionalism" in medicine: clarifying the differences between genetic and nongenetic tests.

Authors:  Michael J Green; Jeffrey R Botkin
Journal:  Ann Intern Med       Date:  2003-04-01       Impact factor: 25.391

Review 6.  Genomic medicine--a primer.

Authors:  Alan E Guttmacher; Francis S Collins
Journal:  N Engl J Med       Date:  2002-11-07       Impact factor: 91.245

Review 7.  Why have we failed to find the low penetrance genetic constituents of common cancers?

Authors:  Neil E Caporaso
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2002-12       Impact factor: 4.254

8.  A vision for the future of genomics research.

Authors:  Francis S Collins; Eric D Green; Alan E Guttmacher; Mark S Guyer
Journal:  Nature       Date:  2003-04-14       Impact factor: 49.962

9.  Genetic exceptionalism & legislative pragmatism.

Authors:  Mark A Rothstein
Journal:  Hastings Cent Rep       Date:  2005 Jul-Aug       Impact factor: 2.683

10.  Implications of the Human Genome Project for medical science.

Authors:  F S Collins; V A McKusick
Journal:  JAMA       Date:  2001-02-07       Impact factor: 56.272

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  12 in total

1.  Users' motivations to purchase direct-to-consumer genome-wide testing: an exploratory study of personal stories.

Authors:  Yeyang Su; Heidi C Howard; Pascal Borry
Journal:  J Community Genet       Date:  2011-05-28

2.  Legislation on direct-to-consumer genetic testing in seven European countries.

Authors:  Pascal Borry; Rachel E van Hellemondt; Dominique Sprumont; Camilla Fittipaldi Duarte Jales; Emmanuelle Rial-Sebbag; Tade Matthias Spranger; Liam Curren; Jane Kaye; Herman Nys; Heidi Howard
Journal:  Eur J Hum Genet       Date:  2012-01-25       Impact factor: 4.246

Review 3.  Genetic screening: A primer for primary care.

Authors:  Anne Andermann; Ingeborg Blancquaert
Journal:  Can Fam Physician       Date:  2010-04       Impact factor: 3.275

Review 4.  Genomics and policymaking: from static models to complex systems?

Authors:  Bartha Maria Knoppers
Journal:  Hum Genet       Date:  2009-02-28       Impact factor: 4.132

5.  Biomarkers in psychiatry.

Authors:  Ilina Singh; Nikolas Rose
Journal:  Nature       Date:  2009-07-09       Impact factor: 49.962

6.  Direct to consumer genetic testing-law and policy concerns in Ireland.

Authors:  Aisling de Paor
Journal:  Ir J Med Sci       Date:  2017-11-25       Impact factor: 1.568

7.  Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access.

Authors:  Hannah Shipman; Samantha Flynn; Carey F MacDonald-Smith; James Brenton; Robin Crawford; Marc Tischkowitz; Nicholas J Hulbert-Williams
Journal:  J Genet Couns       Date:  2017-05-24       Impact factor: 2.537

Review 8.  A critical appraisal of biomarkers in prostate cancer.

Authors:  Vikram M Narayan
Journal:  World J Urol       Date:  2019-04-16       Impact factor: 4.226

9.  Genetics specialists' perspectives on disclosure of genomic incidental findings in the clinical setting.

Authors:  Nancy R Downing; Janet K Williams; Sandra Daack-Hirsch; Martha Driessnack; Christian M Simon
Journal:  Patient Educ Couns       Date:  2012-10-12

Review 10.  Incorporating patient perspectives in the development of a core outcome set for reproductive genetic carrier screening: a sequential systematic review.

Authors:  Ebony Richardson; Alison McEwen; Toby Newton-John; Ashley Crook; Chris Jacobs
Journal:  Eur J Hum Genet       Date:  2022-03-28       Impact factor: 5.351

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