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Literature DB >> 17065625

Selection of retapamulin, a novel pleuromutilin for topical use.

Stephen Rittenhouse¹, Sanjoy Biswas, John Broskey, Lynn McCloskey, Terrance Moore, Sandra Vasey, Joshua West, Magdalena Zalacain, Rimma Zonis, David Payne.

Abstract

The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC(90)s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 microg/ml and 0.016 microg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.

Entities: Chemical Species

Mesh：

Substances：

Year: 2006 PMID： 17065625 PMCID： PMC1635201 DOI： 10.1128/AAC.00178-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

7 in total

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Review 2. Impetigo: an update.

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Journal: Int J Dermatol Date: 2003-04 Impact factor: 2.736

3. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes.

Authors: Kang Yan; Lenore Madden; Anthony E Choudhry; Christine S Voigt; Robert A Copeland; Richard R Gontarek
Journal: Antimicrob Agents Chemother Date: 2006-08-28 Impact factor: 5.191

Review 4. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America.

Authors: George H Talbot; John Bradley; John E Edwards; David Gilbert; Michael Scheld; John G Bartlett
Journal: Clin Infect Dis Date: 2005-01-25 Impact factor: 9.079

5. Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic.

Authors: Stephen Rittenhouse; Christine Singley; Jennifer Hoover; Roni Page; David Payne
Journal: Antimicrob Agents Chemother Date: 2006-11 Impact factor: 5.191

Review 6. Secondary bacterial infections complicating skin lesions.

Authors: Itzhak Brook
Journal: J Med Microbiol Date: 2002-10 Impact factor: 2.472

7. Postantibiotic and post-beta-lactamase inhibitor effects of amoxicillin plus clavulanate.

Authors: C E Thorburn; S J Molesworth; R Sutherland; S Rittenhouse
Journal: Antimicrob Agents Chemother Date: 1996-12 Impact factor: 5.191

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2. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes.

Authors: Kang Yan; Lenore Madden; Anthony E Choudhry; Christine S Voigt; Robert A Copeland; Richard R Gontarek
Journal: Antimicrob Agents Chemother Date: 2006-08-28 Impact factor: 5.191

Review 3. Investigational antimicrobial agents of 2013.

Authors: Michael J Pucci; Karen Bush
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4. Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.

Authors: W Scott Champney; Ward K Rodgers
Journal: Antimicrob Agents Chemother Date: 2007-06-11 Impact factor: 5.191

5. Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic.

Authors: Stephen Rittenhouse; Christine Singley; Jennifer Hoover; Roni Page; David Payne
Journal: Antimicrob Agents Chemother Date: 2006-11 Impact factor: 5.191

6. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates.

Authors: Emilio Pérez-Trallero; Esther Tamayo; Milagrosa Montes; José M García-Arenzana; Victor Iriarte
Journal: Antimicrob Agents Chemother Date: 2011-02-22 Impact factor: 5.191

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9. Establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus Clitopilus passeckerianus.

Authors: Sreedhar Kilaru; Catherine M Collins; Amanda J Hartley; Andy M Bailey; Gary D Foster
Journal: Appl Environ Microbiol Date: 2009-09-18 Impact factor: 4.792

10. Topical retapamulin in the management of infected traumatic skin lesions.

Authors: Ribhi Shawar; Nicole Scangarella-Oman; Marybeth Dalessandro; John Breton; Monique Twynholm; Gang Li; Harmony Garges
Journal: Ther Clin Risk Manag Date: 2009-03-26 Impact factor: 2.423