Literature DB >> 17065626

Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic.

Stephen Rittenhouse1, Christine Singley, Jennifer Hoover, Roni Page, David Payne.   

Abstract

The effect of topically applied retapamulin ointment was evaluated using various dosing regimens in the Staphylococcus aureus and Streptococcus pyogenes wound infection model. Retapamulin (1%, wt/wt) was efficacious using twice-daily (b.i.d.) applications for 4 or 5 days. These data underpinned the decision to evaluate 1% retapamulin b.i.d. in clinical trials.

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Year:  2006        PMID： 17065626      PMCID： PMC1635196          DOI： 10.1128/AAC.00183-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections.

Authors:  J Gisby; J Bryant
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

2.  Selection of retapamulin, a novel pleuromutilin for topical use.

Authors:  Stephen Rittenhouse; Sanjoy Biswas; John Broskey; Lynn McCloskey; Terrance Moore; Sandra Vasey; Joshua West; Magdalena Zalacain; Rimma Zonis; David Payne
Journal:  Antimicrob Agents Chemother       Date:  2006-11       Impact factor: 5.191

3.  Comparative efficacy of gemifloxacin in experimental models of pyelonephritis and wound infection.

Authors:  V Berry; R Page; J Satterfield; C Singley; R Straub; G Woodnutt
Journal:  J Antimicrob Chemother       Date:  2000-04       Impact factor: 5.790

4.  Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): correlations of results from disk diffusion, Etest and reference dilution methods.

Authors:  L M Deshpande; A M Fix; M A Pfaller; R N Jones
Journal:  Diagn Microbiol Infect Dis       Date:  2002-04       Impact factor: 2.803

Review 5.  Fusidic acid in the treatment of methicillin-resistant Staphylococcus aureus.

Authors:  M Whitby
Journal:  Int J Antimicrob Agents       Date:  1999-08       Impact factor: 5.283

Review 6.  Fusidic acid in vitro activity.

Authors:  P Collignon; J Turnidge
Journal:  Int J Antimicrob Agents       Date:  1999-08       Impact factor: 5.283

7.  Prevalence of mupirocin resistance in clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis: results of the Antimicrobial Resistance Surveillance Study of the Paul-Ehrlich-Society for Chemotherapy, 2001.

Authors:  Michael Kresken; Dieter Hafner; Franz-Josef Schmitz; Thomas A Wichelhaus
Journal:  Int J Antimicrob Agents       Date:  2004-06       Impact factor: 5.283

8.  Response of Streptococcus pyogenes to therapy with amoxicillin or amoxicillin-clavulanic acid in a mouse model of mixed infection caused by Staphylococcus aureus and Streptococcus pyogenes.

Authors:  R J Boon; A S Beale
Journal:  Antimicrob Agents Chemother       Date:  1987-08       Impact factor: 5.191

9.  Characterization and quantitation of experimental surgical-wound infections used to evaluate topical antibacterial agents.

Authors:  R J McRipley; R R Whitney
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

Review 10.  Fusidic acid resistance in Staphylococcus aureus.

Authors:  D Dobie; J Gray
Journal:  Arch Dis Child       Date:  2004-01       Impact factor: 3.791
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  12 in total

1.  Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.

Authors:  Roger V Ortines; Yu Wang; Haiyun Liu; Dustin A Dikeman; Bret L Pinsker; Robert J Miller; Sophia E Kim; Nicole E Ackerman; Joe F Rizkallah; LeeAnn T Marcello; Taylor S Cohen; Christine Tkaczyk; Bret R Sellman; Lloyd S Miller
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

2.  Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes.

Authors:  Kang Yan; Lenore Madden; Anthony E Choudhry; Christine S Voigt; Robert A Copeland; Richard R Gontarek
Journal:  Antimicrob Agents Chemother       Date:  2006-08-28       Impact factor: 5.191

3.  Selection of retapamulin, a novel pleuromutilin for topical use.

Authors:  Stephen Rittenhouse; Sanjoy Biswas; John Broskey; Lynn McCloskey; Terrance Moore; Sandra Vasey; Joshua West; Magdalena Zalacain; Rimma Zonis; David Payne
Journal:  Antimicrob Agents Chemother       Date:  2006-11       Impact factor: 5.191

4.  Efficacy of the novel topical antimicrobial agent PXL150 in a mouse model of surgical site infections.

Authors:  Joakim Håkansson; Camilla Björn; Kerstin Lindgren; Emma Sjöström; Veronika Sjöstrand; Margit Mahlapuu
Journal:  Antimicrob Agents Chemother       Date:  2014-03-03       Impact factor: 5.191

Review 5.  Animal models of external traumatic wound infections.

Authors:  Tianhong Dai; Gitika B Kharkwal; Masamitsu Tanaka; Ying-Ying Huang; Vida J Bil de Arce; Michael R Hamblin
Journal:  Virulence       Date:  2011-07-01       Impact factor: 5.882

6.  Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections.

Authors:  John S Cho; Jamie Zussman; Niles P Donegan; Romela Irene Ramos; Nairy C Garcia; Daniel Z Uslan; Yoichiro Iwakura; Scott I Simon; Ambrose L Cheung; Robert L Modlin; Jenny Kim; Lloyd S Miller
Journal:  J Invest Dermatol       Date:  2010-12-30       Impact factor: 8.551

7.  In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice.

Authors:  Yi Guo; Romela Irene Ramos; John S Cho; Niles P Donegan; Ambrose L Cheung; Lloyd S Miller
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

Review 8.  Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections.

Authors:  Lily P H Yang; Susan J Keam
Journal:  Drugs       Date:  2008       Impact factor: 9.546

9.  Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity.

Authors:  Chen Davidovich; Anat Bashan; Tamar Auerbach-Nevo; Rachel D Yaggie; Richard R Gontarek; Ada Yonath
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-08       Impact factor: 11.205

10.  Evaluation of 3 Alcohol-based Agents for Presurgical Skin Preparation in Mice.

Authors:  Monika K Huss; Kerriann M Casey; Jing Hu; Roberta C Moorhead; Helen H Chum
Journal:  J Am Assoc Lab Anim Sci       Date:  2019-11-21       Impact factor: 1.232
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