Literature DB >> 17562806

Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.

W Scott Champney1, Ward K Rodgers.   

Abstract

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.

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Year:  2007        PMID： 17562806      PMCID： PMC2043230          DOI： 10.1128/AAC.00475-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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