OBJECTIVE: Bipolar and cannabis use disorders commonly co-occur during adolescence, and neurochemical studies may help clarify the pathophysiology underlying this co-occurrence. This study compared metabolite concentrations in the left ventral lateral prefrontal cortex among adolescents with bipolar disorder (bipolar group; n = 14), adolescents with a cannabis use disorder (cannabis use group; n = 13), adolescents with cannabis use and bipolar disorders (bipolar and cannabis group; n = 25), and healthy adolescents (healthy controls; n = 15). We hypothesized that adolescents with bipolar disorder (with or without cannabis use disorder) would have decreased N-acetyl aspartate levels in the ventral lateral prefrontal cortex compared to the other groups and that the bipolar and cannabis group would have the lowest N-acetyl aspartate levels of all groups. METHODS: N-acetyl aspartate concentrations in the left ventral lateral prefrontal cortex were obtained using proton magnetic resonance spectroscopy. RESULTS: Adolescents with bipolar disorder showed significantly lower left ventral lateral prefrontal cortex N-acetyl aspartate levels, but post hoc analyses indicated that this was primarily due to increased N-acetyl aspartate levels in the cannabis group. The cannabis use disorder group had significantly higher N-acetyl aspartate levels compared to the bipolar disorder and the bipolar and cannabis groups (p = .0002 and p = .0002, respectively). Pearson correlations revealed a significant positive correlation between amount of cannabis used and N-acetyl aspartate concentrations. CONCLUSIONS: Adolescents with cannabis use disorder showed higher levels of N-acetyl aspartate concentrations that were significantly positively associated with the amount of cannabis used; however, this finding was not present in adolescents with comorbid bipolar disorder.
OBJECTIVE:Bipolar and cannabis use disorders commonly co-occur during adolescence, and neurochemical studies may help clarify the pathophysiology underlying this co-occurrence. This study compared metabolite concentrations in the left ventral lateral prefrontal cortex among adolescents with bipolar disorder (bipolar group; n = 14), adolescents with a cannabis use disorder (cannabis use group; n = 13), adolescents with cannabis use and bipolar disorders (bipolar and cannabis group; n = 25), and healthy adolescents (healthy controls; n = 15). We hypothesized that adolescents with bipolar disorder (with or without cannabis use disorder) would have decreased N-acetyl aspartate levels in the ventral lateral prefrontal cortex compared to the other groups and that the bipolar and cannabis group would have the lowest N-acetyl aspartate levels of all groups. METHODS:N-acetyl aspartate concentrations in the left ventral lateral prefrontal cortex were obtained using proton magnetic resonance spectroscopy. RESULTS: Adolescents with bipolar disorder showed significantly lower left ventral lateral prefrontal cortex N-acetyl aspartate levels, but post hoc analyses indicated that this was primarily due to increased N-acetyl aspartate levels in the cannabis group. The cannabis use disorder group had significantly higher N-acetyl aspartate levels compared to the bipolar disorder and the bipolar and cannabis groups (p = .0002 and p = .0002, respectively). Pearson correlations revealed a significant positive correlation between amount of cannabis used and N-acetyl aspartate concentrations. CONCLUSIONS: Adolescents with cannabis use disorder showed higher levels of N-acetyl aspartate concentrations that were significantly positively associated with the amount of cannabis used; however, this finding was not present in adolescents with comorbid bipolar disorder.
Authors: Melissa P DelBello; Kim M Cecil; Caleb M Adler; John P Daniels; Stephen M Strakowski Journal: Neuropsychopharmacology Date: 2006-06 Impact factor: 7.853
Authors: Caleb M Adler; Melissa P DelBello; Kelly Jarvis; Ari Levine; John Adams; Stephen M Strakowski Journal: Biol Psychiatry Date: 2006-10-06 Impact factor: 13.382
Authors: Nick C Patel; Melissa P DelBello; Kim M Cecil; Caleb M Adler; Holly S Bryan; Kevin E Stanford; Stephen M Strakowski Journal: Biol Psychiatry Date: 2006-11-01 Impact factor: 13.382
Authors: K K Bucholz; R Cadoret; C R Cloninger; S H Dinwiddie; V M Hesselbrock; J I Nurnberger; T Reich; I Schmidt; M A Schuckit Journal: J Stud Alcohol Date: 1994-03
Authors: Kelly Jarvis; Melissa P DelBello; Neil Mills; Igor Elman; Stephen M Strakowski; Caleb M Adler Journal: J Child Adolesc Psychopharmacol Date: 2008-12 Impact factor: 2.576
Authors: Jessica J Black; Jaimee L Heffner; Robert M Anthenelli; Jennifer N Beavers; Allison Albertz; Thomas Blom; Caleb Adler; Melissa P Delbello Journal: J Dual Diagn Date: 2012-02-13
Authors: Marisa M Silveri; Alecia D Dager; Julia E Cohen-Gilbert; Jennifer T Sneider Journal: Neurosci Biobehav Rev Date: 2016-07-01 Impact factor: 8.989