OBJECTIVE: Identifying neurochemical alterations in adolescent bipolar depression may enhance our understanding of the neurophysiology of bipolar disorder across the age spectrum. The objective of this study was to compare in vivo neurometabolite concentrations in bipolar adolescents with a depressed episode and healthy adolescents using proton magnetic resonance spectroscopy ((1)H MRS). METHOD: Bipolar adolescents with a depressed episode (n = 28) and healthy adolescents (n = 10) underwent a (1)H MRS scan. Anterior cingulate (ACC) and left and right ventral lateral prefrontal (LVLPFC, RVLPFC) metabolite concentrations were calculated and compared between groups using analysis of covariance (ANCOVA). RESULTS: ANCOVA showed significant group differences in ACC N-acetyl-aspartate (NAA) (F(1,33) = 17.8, p = 0.0002), LVLPFC choline (Cho) (F(1,32) = 13.1, p = 0.001), creatine/phosphocreatine (Cr) (F(1,32) = 18.5, p = 0.0002), and NAA (F(1,32) = 13.6, p = 0.0008), and RVLPFC Cr (F(1,32) = 9.6, p = 0.004), mI (F(1,32) = 11.1, p = 0.002), and NAA (F(1,32) = 11.4, p = 0.002) concentrations. In general, the bipolar depressed group had higher neurometabolite concentrations than the healthy group. CONCLUSIONS: There may be localized alterations in brain neurometabolites in adolescents with bipolar depression. Limitations include lack of bipolar adolescents in other mood states and potential confounding effects of prior psychotropic medication use. Confirmatory (1)H MRS studies in larger samples of youths with bipolar depression are needed.
OBJECTIVE: Identifying neurochemical alterations in adolescent bipolar depression may enhance our understanding of the neurophysiology of bipolar disorder across the age spectrum. The objective of this study was to compare in vivo neurometabolite concentrations in bipolar adolescents with a depressed episode and healthy adolescents using proton magnetic resonance spectroscopy ((1)H MRS). METHOD:Bipolar adolescents with a depressed episode (n = 28) and healthy adolescents (n = 10) underwent a (1)H MRS scan. Anterior cingulate (ACC) and left and right ventral lateral prefrontal (LVLPFC, RVLPFC) metabolite concentrations were calculated and compared between groups using analysis of covariance (ANCOVA). RESULTS: ANCOVA showed significant group differences in ACC N-acetyl-aspartate (NAA) (F(1,33) = 17.8, p = 0.0002), LVLPFC choline (Cho) (F(1,32) = 13.1, p = 0.001), creatine/phosphocreatine (Cr) (F(1,32) = 18.5, p = 0.0002), and NAA (F(1,32) = 13.6, p = 0.0008), and RVLPFC Cr (F(1,32) = 9.6, p = 0.004), mI (F(1,32) = 11.1, p = 0.002), and NAA (F(1,32) = 11.4, p = 0.002) concentrations. In general, the bipolar depressed group had higher neurometabolite concentrations than the healthy group. CONCLUSIONS: There may be localized alterations in brain neurometabolites in adolescents with bipolar depression. Limitations include lack of bipolar adolescents in other mood states and potential confounding effects of prior psychotropic medication use. Confirmatory (1)H MRS studies in larger samples of youths with bipolar depression are needed.
Authors: Juan R Bustillo; Laura M Rowland; John Lauriello; Helen Petropoulos; Roger Hammond; Blaine Hart; William M Brooks Journal: Am J Psychiatry Date: 2002-01 Impact factor: 18.112
Authors: B Geller; B Zimerman; M Williams; K Bolhofner; J L Craney; M P DelBello; C Soutullo Journal: J Am Acad Child Adolesc Psychiatry Date: 2001-04 Impact factor: 8.829
Authors: C M Moore; J L Breeze; S A Gruber; S M Babb; B B Frederick; R A Villafuerte; A L Stoll; J Hennen; D A Yurgelun-Todd; B M Cohen; P F Renshaw Journal: Bipolar Disord Date: 2000-09 Impact factor: 6.744
Authors: Mark A Frye; June Watzl; Shida Banakar; Joseph O'Neill; Jim Mintz; Pablo Davanzo; Jeffrey Fischer; Jason W Chirichigno; Joseph Ventura; Shana Elman; John Tsuang; Irwin Walot; M Albert Thomas Journal: Neuropsychopharmacology Date: 2007-04-11 Impact factor: 7.853
Authors: Manpreet K Singh; Booil Jo; Nancy E Adleman; Meghan Howe; Layla Bararpour; Ryan G Kelley; Daniel Spielman; Kiki D Chang Journal: Psychiatry Res Date: 2013-09-09 Impact factor: 3.222
Authors: Xian-Feng Shi; Douglas G Kondo; Young-Hoon Sung; Tracy L Hellem; Kristen K Fiedler; Eun-Kee Jeong; Rebekah S Huber; Perry F Renshaw Journal: Bipolar Disord Date: 2012-07-20 Impact factor: 6.744
Authors: D G Kondo; T L Hellem; X-F Shi; Y H Sung; A P Prescot; T S Kim; R S Huber; L N Forrest; P F Renshaw Journal: AJNR Am J Neuroradiol Date: 2014-02-20 Impact factor: 3.825
Authors: Nisha Singh; Ann L Sharpley; Uzay E Emir; Charles Masaki; Mohammad M Herzallah; Mark A Gluck; Trevor Sharp; Catherine J Harmer; Sridhar R Vasudevan; Philip J Cowen; Grant C Churchill Journal: Neuropsychopharmacology Date: 2015-11-23 Impact factor: 7.853
Authors: Xian-Feng Shi; Lauren N Forrest; M Danielle Kuykendall; Andrew P Prescot; Young-Hoon Sung; Rebekah S Huber; Tracy L Hellem; Eun-Kee Jeong; Perry F Renshaw; Douglas G Kondo Journal: J Affect Disord Date: 2014-06-02 Impact factor: 4.839