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Literature DB >> 22771947

Cdc6: a multi-functional molecular switch with critical role in carcinogenesis.

Thodoris G Petrakis¹, Konstantinos Vougas, Vassilis G Gorgoulis.

Abstract

Research in the last decade revealed an additional role for the Replication Licensing Factor Cdc6 in transcriptional regulation. This novel function has been linked to human cancer development. Here, we summarize all the findings arguing over a role of Cdc6 as a transcriptional repressor and shed light toward new research directions for this field.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22771947 PMCID： PMC3616082 DOI： 10.4161/trns.20301

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

40 in total

1. Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region.

Authors: D M Cimbora; D Schübeler; A Reik; J Hamilton; C Francastel; E M Epner; M Groudine
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

2. Developmental regulation of DNA replication timing at the human beta globin locus.

Authors: I Simon; T Tenzen; R Mostoslavsky; E Fibach; L Lande; E Milot; J Gribnau; F Grosveld; P Fraser; H Cedar
Journal: EMBO J Date: 2001-11-01 Impact factor: 11.598

3. Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding.

Authors: D G Lee; A M Makhov; R D Klemm; J D Griffith; S P Bell
Journal: EMBO J Date: 2000-09-01 Impact factor: 11.598

Review 4. Epithelial-mesenchymal transitions in tumour progression.

Authors: Jean Paul Thiery
Journal: Nat Rev Cancer Date: 2002-06 Impact factor: 60.716

Review 5. Linking DNA replication to heterochromatin silencing and epigenetic inheritance.

Authors: Qing Li; Zhiguo Zhang
Journal: Acta Biochim Biophys Sin (Shanghai) Date: 2012-01 Impact factor: 3.848

6. CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex.

Authors: M Takayama; T Taira; S M Iguchi-Ariga; H Ariga
Journal: FEBS Lett Date: 2000-07-14 Impact factor: 4.124

7. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro.

Authors: T Mizushima; N Takahashi; B Stillman
Journal: Genes Dev Date: 2000-07-01 Impact factor: 11.361

8. ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction.

Authors: M A Takayama; T Taira; K Tamai; S M Iguchi-Ariga; H Ariga
Journal: Genes Cells Date: 2000-06 Impact factor: 1.891

9. Replication dynamics of the yeast genome.

Authors: M K Raghuraman; E A Winzeler; D Collingwood; S Hunt; L Wodicka; A Conway; D J Lockhart; R W Davis; B J Brewer; W L Fangman
Journal: Science Date: 2001-10-05 Impact factor: 47.728

10. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.

Authors: Maria Sideridou; Roubini Zakopoulou; Konstantinos Evangelou; Michalis Liontos; Athanassios Kotsinas; Emmanouil Rampakakis; Sarantis Gagos; Kaoru Kahata; Kristina Grabusic; Kalliopi Gkouskou; Ioannis P Trougakos; Evangelos Kolettas; Alexandros G Georgakilas; Sinisa Volarevic; Aristides G Eliopoulos; Maria Zannis-Hadjopoulos; Aristidis Moustakas; Vassilis G Gorgoulis
Journal: J Cell Biol Date: 2011-12-26 Impact factor: 10.539

13 in total

1. Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis.

Authors: Zhongxia Wu; Wei Guo; Yingtian Xie; Shutang Zhou
Journal: J Biol Chem Date: 2016-01-04 Impact factor: 5.157

2. Transcriptome analysis of neoplastic hemocytes in soft-shell clams Mya arenaria: Focus on cell cycle molecular mechanism.

Authors: Ahmed Siah; Patty McKenna; Franck C J Berthe; Luis O B Afonso; Jean-Michel Danger
Journal: Results Immunol Date: 2013-11-01

3. miR-26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression.

Authors: Ting-Yi Sun; Hong-Jian Xie; Hui He; Zhen Li; Ling-Fei Kong
Journal: Am J Transl Res Date: 2016-02-15 Impact factor: 4.060

4. Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia.

Authors: Roberto Bellelli; Donata Vitagliano; Giorgia Federico; Pina Marotta; Anna Tamburrino; Paolo Salerno; Orlando Paciello; Serenella Papparella; Jeffrey A Knauf; James A Fagin; Samuel Refetoff; Giancarlo Troncone; Massimo Santoro
Journal: Mol Cell Endocrinol Date: 2017-06-23 Impact factor: 4.102

5. Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.

Authors: Sansan Chen; Xinglu Chen; Gui'e Xie; Yue He; Daoyu Yan; Dianpeng Zheng; Shi Li; Xinyang Fu; Yeping Li; Xiang Pang; Zhiming Hu; Hongwei Li; Wanlong Tan; Jinlong Li
Journal: Oncotarget Date: 2016-06-28

6. A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.

Authors: Eirini-Stavroula Komseli; Ioannis S Pateras; Thorbjørn Krejsgaard; Konrad Stawiski; Sophia V Rizou; Alexander Polyzos; Fani-Marlen Roumelioti; Maria Chiourea; Ioanna Mourkioti; Eleni Paparouna; Christos P Zampetidis; Sentiljana Gumeni; Ioannis P Trougakos; Dafni-Eleftheria Pefani; Eric O'Neill; Sarantis Gagos; Aristides G Eliopoulos; Wojciech Fendler; Dipanjan Chowdhury; Jiri Bartek; Vassilis G Gorgoulis
Journal: BMC Genomics Date: 2018-01-10 Impact factor: 3.969