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Literature DB >> 17047853

Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein.

Manfred T Reetz¹, Jérôme J-P Peyralans, Andrea Maichele, Yu Fu, Matthias Maywald.

Abstract

The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal-ligand centers anchored to proteins has been implemented experimentally for the first time.

Entities: Chemical

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Year: 2006 PMID： 17047853 DOI： 10.1039/b610461d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

26 in total

1. Covalent Anchor Positions Play an Important Role in Tuning Catalytic Properties of a Rationally Designed MnSalen-containing Metalloenzyme.

Authors: Dewain K Garner; Lei Liang; David A Barrios; Jun-Long Zhang; Yi Lu
Journal: ACS Catal Date: 2011-09-02 Impact factor: 13.084

Review 2. Directed evolution drives the next generation of biocatalysts.

Authors: Nicholas J Turner
Journal: Nat Chem Biol Date: 2009-08 Impact factor: 15.040

3. Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.

Authors: Jun-Long Zhang; Dewain K Garner; Lei Liang; Qian Chen; Yi Lu
Journal: Chem Commun (Camb) Date: 2008-02-04 Impact factor: 6.222

4. Unravelling novel synergies between organometallic and biological partners: a quantum mechanics/molecular mechanics study of an artificial metalloenzyme.

Authors: Elisabeth Ortega-Carrasco; Agustí Lledós; Jean-Didier Maréchal
Journal: J R Soc Interface Date: 2014-07-06 Impact factor: 4.118

Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein.

1. Covalent Anchor Positions Play an Important Role in Tuning Catalytic Properties of a Rationally Designed MnSalen-containing Metalloenzyme.

Review 2. Directed evolution drives the next generation of biocatalysts.

3. Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.

4. Unravelling novel synergies between organometallic and biological partners: a quantum mechanics/molecular mechanics study of an artificial metalloenzyme.

5. Directed evolution of artificial metalloenzymes for in vivo metathesis.

6. Preparation, Characterization, and Oxygenase Activity of a Photocatalytic Artificial Enzyme.

7. Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.

8. Counter propagation artificial neural networks modeling of an enantioselectivity of artificial metalloenzymes.

9. Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activation.

10. A general method for artificial metalloenzyme formation through strain-promoted azide-alkyne cycloaddition.