Literature DB >> 17005833

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

Lisa Y Chiang1, Daniele E Ejzykowicz, Zong-Qiang Tian, Leonard Katz, Scott G Filler.   

Abstract

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

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Year:  2006        PMID： 17005833      PMCID： PMC1610070          DOI： 10.1128/AAC.00558-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  On the mechanism of action of the myxobacterial fungicide ambruticin.

Authors:  P Knauth; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  2000-10       Impact factor: 2.649

2.  Ambruticin (W7783), a new antifungal antibiotic.

Authors:  S M Ringel; R C Greenough; S Roemer; D Connor; A L Gutt; B Blair; G Kanter
Journal:  J Antibiot (Tokyo)       Date:  1977-05       Impact factor: 2.649

3.  Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.

Authors:  Lisa F Shubitz; John N Galgiani; Zong-Qiang Tian; Ziyang Zhong; Pieter Timmermans; Leonard Katz
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

4.  In vitro synergistic interaction between amphotericin B and pentamidine against Scedosporium prolificans.

Authors:  Javier Afeltra; Eric Dannaoui; Jacques F G M Meis; Juan L Rodriguez-Tudela; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

5.  Novel inhalational murine model of invasive pulmonary aspergillosis.

Authors:  Donald C Sheppard; Gunter Rieg; Lisa Y Chiang; Scott G Filler; John E Edwards; Ashraf S Ibrahim
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

6.  In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model.

Authors:  Qiu N Sun; Laura K Najvar; Rosie Bocanegra; David Loebenberg; John R Graybill
Journal:  Antimicrob Agents Chemother       Date:  2002-07       Impact factor: 5.191
  6 in total
  4 in total

1.  The antifungal polyketide ambruticin targets the HOG pathway.

Authors:  Leandro Vetcher; Hugo G Menzella; Toshiaki Kudo; Takayuki Motoyama; Leonard Katz
Journal:  Antimicrob Agents Chemother       Date:  2007-08-13       Impact factor: 5.191

2.  The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin.

Authors:  Anita Dongo; Nelly Bataillé-Simoneau; Claire Campion; Thomas Guillemette; Bruno Hamon; Béatrice Iacomi-Vasilescu; Leonard Katz; Philippe Simoneau
Journal:  Appl Environ Microbiol       Date:  2008-11-14       Impact factor: 4.792

Review 3.  Rodent Models of Invasive Aspergillosis due to Aspergillus fumigatus: Still a Long Path toward Standardization.

Authors:  Guillaume Desoubeaux; Carolyn Cray
Journal:  Front Microbiol       Date:  2017-05-16       Impact factor: 5.640

Review 4.  Current Landscape of Coccidioidomycosis.

Authors:  Ryan Boro; Prema C Iyer; Maciej A Walczak
Journal:  J Fungi (Basel)       Date:  2022-04-17
  4 in total

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