Literature DB >> 17698623

The antifungal polyketide ambruticin targets the HOG pathway.

Leandro Vetcher1, Hugo G Menzella, Toshiaki Kudo, Takayuki Motoyama, Leonard Katz.   

Abstract

The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.

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Year:  2007        PMID： 17698623      PMCID： PMC2043265          DOI： 10.1128/AAC.00369-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  On the mechanism of action of the myxobacterial fungicide ambruticin.

Authors:  P Knauth; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  2000-10       Impact factor: 2.649

2.  Identification of OS-2 MAP kinase-dependent genes induced in response to osmotic stress, antifungal agent fludioxonil, and heat shock in Neurospora crassa.

Authors:  Rieko Noguchi; Shinpei Banno; Ryota Ichikawa; Fumiyasu Fukumori; Akihiko Ichiishi; Makoto Kimura; Isamu Yamaguchi; Makoto Fujimura
Journal:  Fungal Genet Biol       Date:  2006-09-20       Impact factor: 3.495

3.  Osmoregulation and fungicide resistance: the Neurospora crassa os-2 gene encodes a HOG1 mitogen-activated protein kinase homologue.

Authors:  Yan Zhang; Randy Lamm; Christian Pillonel; Stephen Lam; Jin-Rong Xu
Journal:  Appl Environ Microbiol       Date:  2002-02       Impact factor: 4.792

4.  W-7783, a unique antifungal antibiotic.

Authors:  D T Connor; R C Greenough; M von Strandtmann
Journal:  J Org Chem       Date:  1977-11-11       Impact factor: 4.354

5.  Ambruticin (W7783), a new antifungal antibiotic.

Authors:  S M Ringel; R C Greenough; S Roemer; D Connor; A L Gutt; B Blair; G Kanter
Journal:  J Antibiot (Tokyo)       Date:  1977-05       Impact factor: 2.649

Review 6.  Osmotic stress signaling and osmoadaptation in yeasts.

Authors:  Stefan Hohmann
Journal:  Microbiol Mol Biol Rev       Date:  2002-06       Impact factor: 11.056

7.  Whole-genome analysis of two-component signal transduction genes in fungal pathogens.

Authors:  Natalie L Catlett; Olen C Yoder; B Gillian Turgeon
Journal:  Eukaryot Cell       Date:  2003-12

8.  An osmosensing histidine kinase mediates dicarboximide fungicide resistance in Botryotinia fuckeliana (Botrytis cinerea).

Authors:  Wei Cui; Ross E Beever; Stephanie L Parkes; Pauline L Weeds; Matthew D Templeton
Journal:  Fungal Genet Biol       Date:  2002-08       Impact factor: 3.495

9.  Cloning and characterization of the histidine kinase gene Dic1 from Cochliobolus heterostrophus that confers dicarboximide resistance and osmotic adaptation.

Authors:  A Yoshimi; M Tsuda; C Tanaka
Journal:  Mol Genet Genomics       Date:  2004-01-30       Impact factor: 3.291

10.  Dicarboximide resistance in field isolates of Alternaria alternata is mediated by a mutation in a two-component histidine kinase gene.

Authors:  Ian B Dry; Khor H Yuan; Don G Hutton
Journal:  Fungal Genet Biol       Date:  2004-01       Impact factor: 3.495
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  12 in total

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Authors:  Teresa M Lamb; Katelyn E Finch; Deborah Bell-Pedersen
Journal:  Fungal Genet Biol       Date:  2012-01-05       Impact factor: 3.495

Review 2.  The Future of Antifungal Drug Therapy: Novel Compounds and Targets.

Authors:  Caroline Mota Fernandes; Deveney Dasilva; Krupanandan Haranahalli; J Brian McCarthy; John Mallamo; Iwao Ojima; Maurizio Del Poeta
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

3.  The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin.

Authors:  Anita Dongo; Nelly Bataillé-Simoneau; Claire Campion; Thomas Guillemette; Bruno Hamon; Béatrice Iacomi-Vasilescu; Leonard Katz; Philippe Simoneau
Journal:  Appl Environ Microbiol       Date:  2008-11-14       Impact factor: 4.792

4.  Involvement of putative response regulator genes of the rice blast fungus Magnaporthe oryzae in osmotic stress response, fungicide action, and pathogenicity.

Authors:  Takayuki Motoyama; Naoko Ochiai; Masumi Morita; Yuki Iida; Ron Usami; Toshiaki Kudo
Journal:  Curr Genet       Date:  2008-08-23       Impact factor: 3.886

5.  Enantioselective Total Synthesis of the Putative Biosynthetic Intermediate Ambruticin J.

Authors:  Kathryn Trentadue; Chia-Fu Chang; Ansel Nalin; Richard E Taylor
Journal:  Chemistry       Date:  2021-05-27       Impact factor: 5.020

6.  Two-Component Signaling Regulates Osmotic Stress Adaptation via SskA and the High-Osmolarity Glycerol MAPK Pathway in the Human Pathogen Talaromyces marneffei.

Authors:  Kylie J Boyce; Cunwei Cao; Alex Andrianopoulos
Journal:  mSphere       Date:  2016-02-24       Impact factor: 4.389

Review 7.  Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil.

Authors:  T Tristan Brandhorst; Bruce S Klein
Journal:  Food Chem Toxicol       Date:  2018-11-17       Impact factor: 5.572

8.  Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants.

Authors:  Mohammed El-Mowafy; Mahmoud M Bahgat; Ursula Bilitewski
Journal:  BMC Microbiol       Date:  2013-09-17       Impact factor: 3.605

9.  Histidine kinases mediate differentiation, stress response, and pathogenicity in Magnaporthe oryzae.

Authors:  Stefan Jacob; Andrew J Foster; Alexander Yemelin; Eckhard Thines
Journal:  Microbiologyopen       Date:  2014-08-08       Impact factor: 3.139

10.  Hog1p activation by marasmic acid through inhibition of the histidine kinase Sln1p.

Authors:  Stefan Jacob; Anja Schüffler; Eckhard Thines
Journal:  Pest Manag Sci       Date:  2016-03-22       Impact factor: 4.845
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