Literature DB >> 17005834

Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.

Lisa F Shubitz1, John N Galgiani, Zong-Qiang Tian, Ziyang Zhong, Pieter Timmermans, Leonard Katz.   

Abstract

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

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Year:  2006        PMID： 17005834      PMCID： PMC1610061          DOI： 10.1128/AAC.00670-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  On the mechanism of action of the myxobacterial fungicide ambruticin.

Authors:  P Knauth; H Reichenbach
Journal:  J Antibiot (Tokyo)       Date:  2000-10       Impact factor: 2.649

2.  Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice.

Authors:  H B Levine; S M Ringel; J M Cobb
Journal:  Chest       Date:  1978-02       Impact factor: 9.410

3.  Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.

Authors:  Lisa Shubitz; Tao Peng; Robert Perrill; Julie Simons; Kris Orsborn; John N Galgiani
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

Review 4.  Update on antifungals targeted to the cell wall: focus on beta-1,3-glucan synthase inhibitors.

Authors:  N H Georgopapadakou
Journal:  Expert Opin Investig Drugs       Date:  2001-02       Impact factor: 6.206

5.  In vitro and in vivo studies of ambruticin (W7783): new class of antifungal antibiotics.

Authors:  S M Ringel
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191

6.  In vivo studies with ambruticin in murine histoplasmosis.

Authors:  S Shadomy; C J Utz; S White
Journal:  Antimicrob Agents Chemother       Date:  1978-07       Impact factor: 5.191

7.  Experimental chemotherapy of histoplasmosis in nude mice.

Authors:  D M Williams; J R Graybill; D J Drutz
Journal:  Am Rev Respir Dis       Date:  1979-10
  7 in total
  7 in total

1.  The antifungal polyketide ambruticin targets the HOG pathway.

Authors:  Leandro Vetcher; Hugo G Menzella; Toshiaki Kudo; Takayuki Motoyama; Leonard Katz
Journal:  Antimicrob Agents Chemother       Date:  2007-08-13       Impact factor: 5.191

Review 2.  The antifungal pipeline: a reality check.

Authors:  John R Perfect
Journal:  Nat Rev Drug Discov       Date:  2017-05-12       Impact factor: 84.694

3.  Large-Scale Evaluation of In Vitro Amphotericin B, Triazole, and Echinocandin Activity against Coccidioides Species from U.S. Institutions.

Authors:  George R Thompson; Bridget M Barker; Nathan P Wiederhold
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

4.  Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

Authors:  Lisa Y Chiang; Daniele E Ejzykowicz; Zong-Qiang Tian; Leonard Katz; Scott G Filler
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

5.  The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin.

Authors:  Anita Dongo; Nelly Bataillé-Simoneau; Claire Campion; Thomas Guillemette; Bruno Hamon; Béatrice Iacomi-Vasilescu; Leonard Katz; Philippe Simoneau
Journal:  Appl Environ Microbiol       Date:  2008-11-14       Impact factor: 4.792

6.  Enantioselective Total Synthesis of the Putative Biosynthetic Intermediate Ambruticin J.

Authors:  Kathryn Trentadue; Chia-Fu Chang; Ansel Nalin; Richard E Taylor
Journal:  Chemistry       Date:  2021-05-27       Impact factor: 5.020

Review 7.  Current Landscape of Coccidioidomycosis.

Authors:  Ryan Boro; Prema C Iyer; Maciej A Walczak
Journal:  J Fungi (Basel)       Date:  2022-04-17
  7 in total

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