M Pakravan1, A Parsa, M Sanagou, C F Parsa. 1. Wilmer Ophthalmological Institute, Wilmer 233, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-9028, USA.
Abstract
AIMS: To evaluate a possible relationship between central corneal thickness (CCT) and optic disc area in patients with primary open-angle glaucoma (POAG). METHODS: Patients with POAG underwent eye examination, optic disc imaging with the Heidelberg Retina Tomograph II (HRT II) and ultrasound corneal pachymetry. Exclusion criteria were prior ocular surgery and low-quality HRT II images (HRT standard deviation (SD) >50). Pearson's correlation coefficients were calculated to assess the associations between CCT and optic disc area. RESULTS: 212 eyes of 137 patients with POAG were examined. In all, 66 (48%) subjects were women, 104 (76%) were Caucasian, 26 (19%) African-American and 7 (5%) other races. 72 eyes remained after excluding those with prior intraocular surgery and low-quality HRT II images. In a univariate analysis of this group, CCT was inversely correlated with optic disc surface area (Pearson's correlation coefficient r = -0.284, p = 0.036, n = 72). Mean (SD) disc area was 2 (0.53) mm(2) (n = 160). Caucasians had significantly smaller discs (p<0.001) than other races (Caucasian 1.9 (0.47) mm(2) (n = 119), African-Americans 2.4 (0.54) mm(2) (n = 31), other races 2.3 (0.45) mm(2) (n = 10)). CONCLUSION: CCT is inversely correlated to optic disc area. Although thicker corneas have been recognised to cause slight overestimation of true intraocular pressure (IOP), they may also indicate the presence of a substantially smaller, and thus more robust, optic nerve head. People with thinner corneas which slightly underestimate the true IOP may also have larger and more deformable optic discs.
AIMS: To evaluate a possible relationship between central corneal thickness (CCT) and optic disc area in patients with primary open-angle glaucoma (POAG). METHODS:Patients with POAG underwent eye examination, optic disc imaging with the Heidelberg Retina Tomograph II (HRT II) and ultrasound corneal pachymetry. Exclusion criteria were prior ocular surgery and low-quality HRT II images (HRT standard deviation (SD) >50). Pearson's correlation coefficients were calculated to assess the associations between CCT and optic disc area. RESULTS: 212 eyes of 137 patients with POAG were examined. In all, 66 (48%) subjects were women, 104 (76%) were Caucasian, 26 (19%) African-American and 7 (5%) other races. 72 eyes remained after excluding those with prior intraocular surgery and low-quality HRT II images. In a univariate analysis of this group, CCT was inversely correlated with optic disc surface area (Pearson's correlation coefficient r = -0.284, p = 0.036, n = 72). Mean (SD) disc area was 2 (0.53) mm(2) (n = 160). Caucasians had significantly smaller discs (p<0.001) than other races (Caucasian 1.9 (0.47) mm(2) (n = 119), African-Americans 2.4 (0.54) mm(2) (n = 31), other races 2.3 (0.45) mm(2) (n = 10)). CONCLUSION: CCT is inversely correlated to optic disc area. Although thicker corneas have been recognised to cause slight overestimation of true intraocular pressure (IOP), they may also indicate the presence of a substantially smaller, and thus more robust, optic nerve head. People with thinner corneas which slightly underestimate the true IOP may also have larger and more deformable optic discs.
Authors: Arne Viestenz; Nina Wakili; Anselm G M Jünemann; Folkert K Horn; Christian Y Mardin Journal: Graefes Arch Clin Exp Ophthalmol Date: 2003-07-25 Impact factor: 3.117
Authors: Linda M Zangwill; Robert N Weinreb; Charles C Berry; Amanda R Smith; Keri A Dirkes; Anne L Coleman; Jody R Piltz-Seymour; Jeffrey M Liebmann; George A Cioffi; Gary Trick; James D Brandt; Mae O Gordon; Michael A Kass Journal: Arch Ophthalmol Date: 2004-01
Authors: Federico Saenz-Frances; Luis Jañez; Lara Borrego-Sanz; Clara Berrozpe-Villabona; Jose Maria Martinez-de-la-Casa; Laura Morales-Fernandez; Julian Garcia-Sanchez; Enrique Santos-Bueso; Julian Garcia-Feijoo Journal: Int J Ophthalmol Date: 2015-12-18 Impact factor: 1.779
Authors: Efstathios T Detorakis; Emilia Grammenandi; Ioannis G Pallikaris; Miltiadis K Tsilimbaris Journal: J Ophthalmol Date: 2010-07-13 Impact factor: 1.909