Sophia Y Wang1, Ronald Melles, Shan C Lin. 1. *Department of Ophthalmology, University of California, San Francisco, San Francisco †Department of Ophthalmology, Kaiser Permanente Northern California, Redwood City Medical Center, Redwood City, CA.
Abstract
PURPOSE: To investigate the relationship between central corneal thickness (CCT) and demographics, and determine whether CCT may be a substantial mediator of the relationships between glaucoma and its demographic risk factors. METHODS: This cross-sectional study included patients in the Kaiser Permanente Northern California health plan from January 1, 2007 to December 31, 2011 who were 40 years and older and had a documented CCT measurement (N=81,082). Those with any cornea-related diagnoses or a history of corneal refractive surgery were excluded. Demographic characteristics, including age, sex, and race/ethnicity, as well as clinical information including glaucoma-related diagnosis, diabetic status, CCT, and intraocular pressure were gathered from the electronic medical record. RESULTS: Multivariate linear regression analysis indicated that female sex, increased age, and black race were significantly associated with thinner corneas. A subgroup analysis among Asians revealed that Chinese, Japanese, and Koreans had corneas 6 to 13 µm thicker than South and Southeast Asians, Filipinos, and Pacific Islanders for each diagnosis (P<0.001). In our population, 24.5% (N=19878) had some form of open-angle glaucoma; 21.9% (N=17,779) did not have any glaucoma-related diagnosis. Variation in CCT accounted for only 6.68% [95% confidence interval (CI), 6.14%-7.24%] of the increased risk of open-angle glaucoma seen with increasing age, but explained as much as 29.4% (95% CI, 27.0%-32.6%) of the increased risk of glaucoma seen among blacks, and 29.5% (95% CI, 23.5%-37.0%) of the increased risk of glaucoma seen among Hispanics. CONCLUSIONS: CCT seems to explain a substantial portion of the increased risk of glaucoma seen among blacks and Hispanics.
PURPOSE: To investigate the relationship between central corneal thickness (CCT) and demographics, and determine whether CCT may be a substantial mediator of the relationships between glaucoma and its demographic risk factors. METHODS: This cross-sectional study included patients in the Kaiser Permanente Northern California health plan from January 1, 2007 to December 31, 2011 who were 40 years and older and had a documented CCT measurement (N=81,082). Those with any cornea-related diagnoses or a history of corneal refractive surgery were excluded. Demographic characteristics, including age, sex, and race/ethnicity, as well as clinical information including glaucoma-related diagnosis, diabetic status, CCT, and intraocular pressure were gathered from the electronic medical record. RESULTS: Multivariate linear regression analysis indicated that female sex, increased age, and black race were significantly associated with thinner corneas. A subgroup analysis among Asians revealed that Chinese, Japanese, and Koreans had corneas 6 to 13 µm thicker than South and Southeast Asians, Filipinos, and Pacific Islanders for each diagnosis (P<0.001). In our population, 24.5% (N=19878) had some form of open-angle glaucoma; 21.9% (N=17,779) did not have any glaucoma-related diagnosis. Variation in CCT accounted for only 6.68% [95% confidence interval (CI), 6.14%-7.24%] of the increased risk of open-angle glaucoma seen with increasing age, but explained as much as 29.4% (95% CI, 27.0%-32.6%) of the increased risk of glaucoma seen among blacks, and 29.5% (95% CI, 23.5%-37.0%) of the increased risk of glaucoma seen among Hispanics. CONCLUSIONS:CCT seems to explain a substantial portion of the increased risk of glaucoma seen among blacks and Hispanics.
Authors: Robert J Casson; Lekha M Abraham; Henry S Newland; James Muecke; Thomas Sullivan; Dinesh Selva; Than Aung Journal: Arch Ophthalmol Date: 2008-07
Authors: Mae O Gordon; Julia A Beiser; James D Brandt; Dale K Heuer; Eve J Higginbotham; Chris A Johnson; John L Keltner; J Philip Miller; Richard K Parrish; M Roy Wilson; Michael A Kass Journal: Arch Ophthalmol Date: 2002-06
Authors: Ling Shen; Ronald B Melles; Ravikanth Metlapally; Lisa Barcellos; Catherine Schaefer; Neil Risch; Lisa J Herrinton; Christine Wildsoet; Eric Jorgenson Journal: Ophthalmology Date: 2015-08-08 Impact factor: 12.079
Authors: Ellen E Freeman; Mark R Lesk; Paul Harasymowycz; Daniel Desjardins; Veronica Flores; Hortence Kamga; Gisèle Li Journal: Medicine (Baltimore) Date: 2016-08 Impact factor: 1.889
Authors: Rebecca King; Felix L Struebing; Ying Li; Jiaxing Wang; Allison Ashley Koch; Jessica N Cooke Bailey; Puya Gharahkhani; Stuart MacGregor; R Rand Allingham; Michael A Hauser; Janey L Wiggs; Eldon E Geisert Journal: PLoS Genet Date: 2018-01-25 Impact factor: 5.917