| Literature DB >> 16959973 |
Maria Selmer1, Christine M Dunham, Frank V Murphy, Albert Weixlbaumer, Sabine Petry, Ann C Kelley, John R Weir, V Ramakrishnan.
Abstract
The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation.Entities:
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Year: 2006 PMID： 16959973 DOI： 10.1126/science.1131127
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728