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Literature DB >> 16868452

DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.

Michele Milanese¹, Ludovica Segat, Alessandra Pontillo, Luiz Claudio Arraes, José Luiz de Lima Filho, Sergio Crovella.

Abstract

In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.

Entities: Disease Gene Mutation Species

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Year: 2006 PMID： 16868452 DOI： 10.1097/01.aids.0000238417.05819.40

Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177

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Cited

28 in total

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Journal: Infect Immun Date: 2014-01-22 Impact factor: 3.441

Review 2. Defensins in viral infections.

Authors: Jian Ding; Yi-Ying Chou; Theresa L Chang
Journal: J Innate Immun Date: 2009-06-24 Impact factor: 7.349

10. Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes.

Authors: Andrea A Kalus; L Page Fredericks; Beth M Hacker; Henrik Dommisch; Richard B Presland; Janet R Kimball; Beverly A Dale
Journal: BMC Oral Health Date: 2009-08-27 Impact factor: 2.757

DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.

1. Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections.

Review 2. Defensins in viral infections.

3. DEFB1 polymorphisms and HIV-1 mother-to-child transmission in Zambian population.

4. Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women.

5. Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals.

Review 6. The roles of antimicrobial peptides in innate host defense.

Review 7. Susceptibility to infectious diseases based on antimicrobial peptide production.

Review 8. Host genetics influences on HIV type-1 disease.

9. A Fast Method for DEFB1 - 44C/G SNP Genotyping in Brazilian Patients with Periodontitis.

10. Association of a genetic polymorphism (-44 C/G SNP) in the human DEFB1 gene with expression and inducibility of multiple beta-defensins in gingival keratinocytes.