AIM: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. MATERIAL AND METHODS: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients. RESULTS: The results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. CONCLUSION: Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.
AIM: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabeticpatients with or without periodontitis in comparison to healthy controls. MATERIAL AND METHODS: We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabeticpatients and healthy control patients. RESULTS: The results indicate that there are no differences in distribution between groups and that in diabetic periodontitispatients the homozygous mutant could be found more frequently. CONCLUSION: Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitispatients and the influence of the peptide in periodontal pathogens.
Authors: H P Jia; B C Schutte; A Schudy; R Linzmeier; J M Guthmiller; G K Johnson; B F Tack; J P Mitros; A Rosenthal; T Ganz; P B McCray Journal: Gene Date: 2001-01-24 Impact factor: 3.688
Authors: Carrie Q Sun; Rebecca Arnold; Carina Fernandez-Golarz; Amanda B Parrish; Tara Almekinder; Ju He; Shuk-mei Ho; Pavel Svoboda; Jan Pohl; Fray F Marshall; John A Petros Journal: Cancer Res Date: 2006-09-01 Impact factor: 12.701