Literature DB >> 20375599

Defensins in viral infections.

Jian Ding1, Yi-Ying Chou, Theresa L Chang.   

Abstract

Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the defensin, virus and target cell. Regulation of viral infection by defensins is achieved by multiple mechanisms. This review focuses on the interplay between defensins and viral infections, the mechanisms of action of defensins and the in vivo studies of the role of defensins in viral infections. Copyright 2009 S. Karger AG, Basel.

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Year:  2009        PMID： 20375599      PMCID： PMC5673487          DOI： 10.1159/000226256

Source DB:  PubMed          Journal:  J Innate Immun        ISSN： 1662-811X            Impact factor:   7.349


  69 in total

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Review 3.  Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.

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5.  Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry.

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6.  A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.

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Journal:  AIDS       Date:  2004-07-23       Impact factor: 4.177

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8.  Mechanism of adenovirus neutralization by Human alpha-defensins.

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Journal:  J Allergy Clin Immunol       Date:  2007-03-13       Impact factor: 10.793
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  38 in total

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Review 3.  Insect antimicrobial peptides and their applications.

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4.  Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia.

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5.  Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.

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6.  Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti.

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-28       Impact factor: 11.205

Review 7.  The Expanding Role of Biomarkers in Diagnosing Infection in Total Joint Arthroplasty: A Review of Current Literature.

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8.  Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239.

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Review 10.  The vaginal microbiota, host defence and reproductive physiology.

Authors:  Steven B Smith; Jacques Ravel
Journal:  J Physiol       Date:  2016-05-05       Impact factor: 5.182
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