Literature DB >> 16856198

Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII.

Mohamed S Abdelfattah1, Jürgen Rohr.   

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Year:  2006        PMID: 16856198      PMCID: PMC4480643          DOI: 10.1002/anie.200600511

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN: 1433-7851            Impact factor:   15.336


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  39 in total

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2.  Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

Authors:  Mohammad Nur-e-Alam; Carmen Méndez; José A Salas; Jürgen Rohr
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3.  Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.

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Review 5.  Treatment of malignant hypercalcaemia.

Authors:  J Hurtado; P Esbrit
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6.  The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-02       Impact factor: 15.336

7.  Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target.

Authors:  Lily L Remsing; Hamid R Bahadori; Giuseppina M Carbone; Eileen M McGuffie; Carlo V Catapano; Jürgen Rohr
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8.  Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction.

Authors:  Christian Hertweck; Longkuan Xiang; John A Kalaitzis; Qian Cheng; Michelle Palzer; Bradley S Moore
Journal:  Chem Biol       Date:  2004-04

9.  Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.

Authors:  Robert J Ferrante; Hoon Ryu; James K Kubilus; Santosh D'Mello; Katharine L Sugars; Junghee Lee; Peiyuan Lu; Karen Smith; Susan Browne; M Flint Beal; Bruce S Kristal; Irina G Stavrovskaya; Sandra Hewett; David C Rubinsztein; Brett Langley; Rajiv R Ratan
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10.  Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.

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2.  Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

Authors:  Katherine S Ryan
Journal:  PLoS One       Date:  2011-08-18       Impact factor: 3.240

3.  Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.

Authors:  Daniel Zabala; Lijiang Song; Yousef Dashti; Gregory L Challis; José A Salas; Carmen Méndez
Journal:  Microb Cell Fact       Date:  2020-05-24       Impact factor: 5.328

4.  Comparative genomics study reveals Red Sea Bacillus with characteristics associated with potential microbial cell factories (MCFs).

Authors:  G Othoum; S Prigent; A Derouiche; L Shi; A Bokhari; S Alamoudi; S Bougouffa; X Gao; R Hoehndorf; S T Arold; T Gojobori; H Hirt; F F Lafi; J Nielsen; V B Bajic; I Mijakovic; M Essack
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