Literature DB >> 10760873

The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.

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Abstract

Entities:  

Year:  2000        PMID： 10760873     DOI： 10.1002/(sici)1521-3773(20000218)39:4<796::aid-anie796>3.0.co;2-n

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  3 in total

1.  Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII.

Authors:  Mohamed S Abdelfattah; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-08-25       Impact factor: 15.336

2.  A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Authors:  Luz E Núñez; Stephen E Nybo; Javier González-Sabín; María Pérez; Nuria Menéndez; Alfredo F Braña; Khaled A Shaaban; Min He; Francisco Morís; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  J Med Chem       Date:  2012-06-07       Impact factor: 7.446

3.  Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.

Authors:  Daniel Zabala; Lijiang Song; Yousef Dashti; Gregory L Challis; José A Salas; Carmen Méndez
Journal:  Microb Cell Fact       Date:  2020-05-24       Impact factor: 5.328
  3 in total

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