Literature DB >> 16854048

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

Stephen J Baker1, Yong-Kang Zhang, Tsutomu Akama, Agnes Lau, Huchen Zhou, Vincent Hernandez, Weimin Mao, M R K Alley, Virginia Sanders, Jacob J Plattner.   

Abstract

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

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Year:  2006        PMID： 16854048     DOI： 10.1021/jm0603724

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  56 in total

1.  Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts.

Authors:  Adelphe M Mfuh; John D Doyle; Bhuwan Chhetri; Hadi D Arman; Oleg V Larionov
Journal:  J Am Chem Soc       Date:  2016-03-01       Impact factor: 15.419

2.  Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.

Authors:  Sergey V Melnikov; David L Stevens; Xian Fu; Hui Si Kwok; Jin-Tao Zhang; Yue Shen; Jeffery Sabina; Kevin Lee; Harry Lee; Dieter Söll
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-13       Impact factor: 11.205

3.  Error-prone protein synthesis in parasites with the smallest eukaryotic genome.

Authors:  Sergey V Melnikov; Keith D Rivera; Denis Ostapenko; Arthur Makarenko; Neil D Sanscrainte; James J Becnel; Mark J Solomon; Catherine Texier; Darryl J Pappin; Dieter Söll
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-18       Impact factor: 11.205

Review 4.  Targeting Metalloenzymes for Therapeutic Intervention.

Authors:  Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal:  Chem Rev       Date:  2018-09-07       Impact factor: 60.622

Review 5.  Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents.

Authors:  Panpan Zhang; Shutao Ma
Journal:  Medchemcomm       Date:  2019-05-27       Impact factor: 3.597

Review 6.  Molecular recognition with boronic acids-applications in chemical biology.

Authors:  Gillian F Whyte; Ramon Vilar; Rudiger Woscholski
Journal:  J Chem Biol       Date:  2013-06-01

Review 7.  Carbohydrate recognition by boronolectins, small molecules, and lectins.

Authors:  Shan Jin; Yunfeng Cheng; Suazette Reid; Minyong Li; Binghe Wang
Journal:  Med Res Rev       Date:  2010-03       Impact factor: 12.944

Review 8.  Boron chemicals in diagnosis and therapeutics.

Authors:  Bhaskar C Das; Pritam Thapa; Radha Karki; Caroline Schinke; Sasmita Das; Suman Kambhampati; Sushanta K Banerjee; Peter Van Veldhuizen; Amit Verma; Louis M Weiss; Todd Evans
Journal:  Future Med Chem       Date:  2013-04       Impact factor: 3.808

9.  3H-2,1-Benzoxaborole-1-spiro-4'-(5-oxa-3a-aza-4-borapyrene).

Authors:  Beck Robin; Gregg Buell; Paul Kiprof; Victor N Nemykin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-21

Review 10.  From the Test Tube to the Treatment Room: Fundamentals of Boron-containing Compounds and their Relevance to Dermatology.

Authors:  James Q Del Rosso; Jacob J Plattner
Journal:  J Clin Aesthet Dermatol       Date:  2014-02
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