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Literature DB >> 16845428

Microbial cell individuality and the underlying sources of heterogeneity.

Abstract

Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic individuality, a biological phenomenon that is considered to bolster the fitness of populations. Major phenotypes that are characterized by heterogeneity span the breadth of microbiology, in fields ranging from pathogenicity to ecology. The cell cycle, cell ageing and epigenetic regulation are proven drivers of heterogeneity in several of the best-known phenotypic examples. However, the full contribution of factors such as stochastic gene expression is yet to be realized.

Mesh：

Substances：
Antigens, Surface

Year: 2006 PMID： 16845428 DOI： 10.1038/nrmicro1460

Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633

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Cited

183 in total

Review 1. Responding to chemical gradients: bacterial chemotaxis.

Authors: Victor Sourjik; Ned S Wingreen
Journal: Curr Opin Cell Biol Date: 2011-12-09 Impact factor: 8.382

2. Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata.

Authors: Samantha C Halliwell; Matthew C A Smith; Philippa Muston; Sara L Holland; Simon V Avery
Journal: Eukaryot Cell Date: 2011-12-02

3. Biotechnological properties of distillery and laboratory yeasts in response to industrial stresses.

Authors: Fernanda Bravim; Fernando L Palhano; A Alberto R Fernandes; Patricia M B Fernandes
Journal: J Ind Microbiol Biotechnol Date: 2010-06-08 Impact factor: 3.346

4. Microbial scout hypothesis, stochastic exit from dormancy, and the nature of slow growers.

Authors: S Buerger; A Spoering; E Gavrish; C Leslin; L Ling; S S Epstein
Journal: Appl Environ Microbiol Date: 2012-02-24 Impact factor: 4.792

5. Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.

Authors: Longzhu Cui; Hui-min Neoh; Akira Iwamoto; Keiichi Hiramatsu
Journal: Proc Natl Acad Sci U S A Date: 2012-05-29 Impact factor: 11.205

6. Microfluidic carbon-blackened polydimethylsiloxane device with reduced ultra violet background fluorescence for simultaneous two-color ultra violet/visible-laser induced fluorescence detection in single cell analysis.

Authors: Lukas Galla; Dominik Greif; Jan Regtmeier; Dario Anselmetti
Journal: Biomicrofluidics Date: 2012-01-12 Impact factor: 2.800

Microbial cell individuality and the underlying sources of heterogeneity.

Review 1. Responding to chemical gradients: bacterial chemotaxis.

2. Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata.

3. Biotechnological properties of distillery and laboratory yeasts in response to industrial stresses.

4. Microbial scout hypothesis, stochastic exit from dormancy, and the nature of slow growers.

5. Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.

6. Microfluidic carbon-blackened polydimethylsiloxane device with reduced ultra violet background fluorescence for simultaneous two-color ultra violet/visible-laser induced fluorescence detection in single cell analysis.

7. Messy biology and the origins of evolutionary innovations.

8. Grand challenge commentary: Exploiting single-cell variation for new antibiotics.

9. A low-affinity penicillin-binding protein 2x variant is required for heteroresistance in Streptococcus pneumoniae.

10. Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae.