Literature DB >> 16834361

Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvant versus immunosuppression activity.

Masakazu Fujio1, Douglass Wu, Raquel Garcia-Navarro, David D Ho, Moriya Tsuji, Chi-Huey Wong.   

Abstract

Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

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Year:  2006        PMID： 16834361     DOI： 10.1021/ja062740z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  44 in total

1.  Divergent synthetic approach to 6''-modified α-GalCer analogues.

Authors:  Nora Pauwels; Sandrine Aspeslagh; Gerd Vanhoenacker; Koen Sandra; Esther D Yu; Dirk M Zajonc; Dirk Elewaut; Bruno Linclau; Serge Van Calenbergh
Journal:  Org Biomol Chem       Date:  2011-11-01       Impact factor: 3.876

2.  Total synthesis of α-1C-galactosylceramide, an immunostimulatory C-glycosphingolipid, and confirmation of the stereochemistry in the first-generation synthesis.

Authors:  Zheng Liu; Hoe-Sup Byun; Robert Bittman
Journal:  J Org Chem       Date:  2011-10-04       Impact factor: 4.354

Review 3.  Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant.

Authors:  Neal N Padte; Xiangming Li; Moriya Tsuji; Sandhya Vasan
Journal:  Clin Immunol       Date:  2010-12-24       Impact factor: 3.969

Review 4.  Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.

Authors:  Amelia R Hofstetter; Lucy C Sullivan; Aron E Lukacher; Andrew G Brooks
Journal:  Curr Opin Immunol       Date:  2010-10-21       Impact factor: 7.486

5.  Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.

Authors:  Ravinder Raju; Bernard F Castillo; Stewart K Richardson; Meena Thakur; Ryan Severins; Mitchell Kronenberg; Amy R Howell
Journal:  Bioorg Med Chem Lett       Date:  2009-06-06       Impact factor: 2.823

6.  Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand.

Authors:  Jeong-Ju Park; Ji Hyung Lee; Subhash C Ghosh; Gabriel Bricard; Manjunatha M Venkataswamy; Steven A Porcelli; Sung-Kee Chung
Journal:  Bioorg Med Chem Lett       Date:  2008-06-14       Impact factor: 2.823

Review 7.  A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.

Authors:  Sandhya Vasan; Moriya Tsuji
Journal:  Semin Immunol       Date:  2009-12-04       Impact factor: 11.130

Review 8.  Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants.

Authors:  Sungjune Kim; Saif Lalani; Vrajesh V Parekh; Lan Wu; Luc Van Kaer
Journal:  Expert Rev Vaccines       Date:  2008-12       Impact factor: 5.217

9.  Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Authors:  Xiangming Li; Akira Kawamura; Chasity D Andrews; Jessica L Miller; Douglass Wu; Tiffany Tsao; Min Zhang; Deena Oren; Neal N Padte; Steven A Porcelli; Chi-Huey Wong; Stefan H I Kappe; David D Ho; Moriya Tsuji
Journal:  J Immunol       Date:  2015-08-07       Impact factor: 5.422

10.  Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

Authors:  Jin S Im; Pooja Arora; Gabriel Bricard; Alberto Molano; Manjunatha M Venkataswamy; Ian Baine; Elliot S Jerud; Michael F Goldberg; Andres Baena; Karl O A Yu; Rachel M Ndonye; Amy R Howell; Weiming Yuan; Peter Cresswell; Young-Tae Chang; Petr A Illarionov; Gurdyal S Besra; Steven A Porcelli
Journal:  Immunity       Date:  2009-06-19       Impact factor: 31.745
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