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Literature DB >> 19053208

Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants.

Sungjune Kim¹, Saif Lalani, Vrajesh V Parekh, Lan Wu, Luc Van Kaer.

Abstract

Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens in the context of the antigen-presenting molecule CD1d. Upon glycolipid antigen stimulation, iNKT cells rapidly produce copious amounts of immunomodulatory cytokines, leading to potent activation of a variety of innate and adaptive immune cells. These immune-potentiating properties of iNKT cells hold great promise for the development of vaccine adjuvants. This review aims to summarize the immunomodulatory activities of iNKT cell ligands and to discuss prospects for developing iNKT cell-based vaccine adjuvants.

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Year: 2008 PMID： 19053208 PMCID： PMC2680388 DOI： 10.1586/14760584.7.10.1519

Source DB: PubMed Journal: Expert Rev Vaccines ISSN： 1476-0584 Impact factor: 5.217

148 in total

1. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.

Authors: Ian F Hermans; Jonathan D Silk; Uzi Gileadi; Mariolina Salio; Bini Mathew; Gerd Ritter; Richard Schmidt; Adrian L Harris; Lloyd Old; Vincenzo Cerundolo
Journal: J Immunol Date: 2003-11-15 Impact factor: 5.422

2. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.

Authors: Manfred Brigl; Lynn Bry; Sally C Kent; Jenny E Gumperz; Michael B Brenner
Journal: Nat Immunol Date: 2003-10-26 Impact factor: 25.606

3. Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation.

Authors: Michishige Harada; Ken-Ichiro Seino; Hiroshi Wakao; Sakura Sakata; Yuko Ishizuka; Toshihiro Ito; Satoshi Kojo; Toshinori Nakayama; Masaru Taniguchi
Journal: Int Immunol Date: 2004-02 Impact factor: 4.823

Review 4. NKT cells: what's in a name?

Authors: Dale I Godfrey; H Robson MacDonald; Mitchell Kronenberg; Mark J Smyth; Luc Van Kaer
Journal: Nat Rev Immunol Date: 2004-03 Impact factor: 53.106

5. Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity.

Authors: Mie Nieda; Miki Okai; Andrea Tazbirkova; Henry Lin; Ayako Yamaura; Kazuki Ide; Rick Abraham; Takeo Juji; David J Macfarlane; Andrew J Nicol
Journal: Blood Date: 2003-09-25 Impact factor: 22.113

Review 6. CD1: antigen presentation and T cell function.

Authors: Manfred Brigl; Michael B Brenner
Journal: Annu Rev Immunol Date: 2004 Impact factor: 28.527

7. Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.

Authors: Regis A Campos; Marian Szczepanik; Atsuko Itakura; Moe Akahira-Azuma; Stephane Sidobre; Mitchell Kronenberg; Philip W Askenase
Journal: J Exp Med Date: 2003-12-15 Impact factor: 14.307

8. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide.

Authors: Alex Jahng; Igor Maricic; Carlos Aguilera; Susanna Cardell; Ramesh C Halder; Vipin Kumar
Journal: J Exp Med Date: 2004-03-29 Impact factor: 14.307

9. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide.

Authors: John Schmieg; Guangli Yang; Richard W Franck; Moriya Tsuji
Journal: J Exp Med Date: 2003-12-01 Impact factor: 14.307

10. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation.

Authors: Shin-Ichiro Fujii; Kang Liu; Caroline Smith; Anthony J Bonito; Ralph M Steinman
Journal: J Exp Med Date: 2004-06-14 Impact factor: 14.307

13 in total

1. α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma.

Authors: Qianhui Chen; Xuxue Guo; Nishan Deng; Linlin Liu; Shuo Chen; Ailing Wang; Ruiyun Li; Yi Huang; Xuhong Ding; Hongying Yu; Suping Hu; Hanxiang Nie
Journal: J Biol Chem Date: 2019-02-11 Impact factor: 5.157

Review 2. Natural killer T cells in lipoprotein metabolism and atherosclerosis.

Authors: G S Getz; P A Vanderlaan; C A Reardon
Journal: Thromb Haemost Date: 2011-09-22 Impact factor: 5.249

Review 3. Invariant natural killer T cells: bridging innate and adaptive immunity.

Authors: Luc Van Kaer; Vrajesh V Parekh; Lan Wu
Journal: Cell Tissue Res Date: 2010-08-24 Impact factor: 5.249

4. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.

Authors: Vrajesh V Parekh; Saif Lalani; Sungjune Kim; Ramesh Halder; Miyuki Azuma; Hideo Yagita; Vipin Kumar; Lan Wu; Luc Van Kaer
Journal: J Immunol Date: 2009-03-01 Impact factor: 5.422