| Literature DB >> 19535248 |
Ravinder Raju1, Bernard F Castillo, Stewart K Richardson, Meena Thakur, Ryan Severins, Mitchell Kronenberg, Amy R Howell.
Abstract
Four 3''- and 4''-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4''-fluoro analog led to the production of significant levels of IL-2.Entities:
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Year: 2009 PMID： 19535248 PMCID： PMC2710405 DOI： 10.1016/j.bmcl.2009.06.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823