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Literature DB >> 21185784

Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant.

Neal N Padte¹, Xiangming Li, Moriya Tsuji, Sandhya Vasan.

Abstract

Natural killer T (NKT) cells are known to play a role against certain microbial infections, including malaria and HIV, two major global infectious diseases. Strategies that can harness and amplify the immunotherapeutic potential of NKT cells can serve as powerful tools in the fight against such diseases. 7DW8-5, a novel glycolipid, may be one such tool. The interaction of 7DW8-5 with CD1d molecules induces activation of NKT cells, thereby activating various immune-competent cells including dendritic cells (DCs) to provide a significant adjuvant effect for several vaccines. This review discusses the discovery and characterization of 7DW8-5 and the practical considerations of its preclinical and clinical development as a potential glycolipid adjuvant for candidate malaria and HIV vaccines.

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Year: 2010 PMID： 21185784 PMCID： PMC4449275 DOI： 10.1016/j.clim.2010.11.009

Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969

80 in total

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Journal: J Immunol Date: 2001-06-01 Impact factor: 5.422

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Journal: Clin Cancer Res Date: 2002-12 Impact factor: 12.531

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Journal: Proc Natl Acad Sci U S A Date: 1998-05-12 Impact factor: 11.205

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Journal: Mol Ther Date: 2009-06-09 Impact factor: 11.454

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Journal: J Exp Med Date: 2005-05-02 Impact factor: 14.307

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Journal: J Exp Med Date: 2005-12-05 Impact factor: 14.307

26 in total

Review 1. Optimizing NKT cell ligands as vaccine adjuvants.

Authors: Leandro J Carreño; Shalu Sharma Kharkwal; Steven A Porcelli
Journal: Immunotherapy Date: 2014 Impact factor: 4.196

2. Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect.

Authors: Xiangming Li; Jing Huang; Akira Kawamura; Ryota Funakoshi; Steven A Porcelli; Moriya Tsuji
Journal: Vaccine Date: 2017-05-05 Impact factor: 3.641

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Authors: Mark A Exley; Lydia Lynch; Bindu Varghese; Michael Nowak; Nadia Alatrakchi; Steven P Balk
Journal: Clin Immunol Date: 2011-05-13 Impact factor: 3.969

4. Design, Synthesis, and Immunological Evaluation of Benzyloxyalkyl-Substituted 1,2,3-Triazolyl α-GalCer Analogues.

Authors: Yogesh Kumar Verma; Bonam Srinivasa Reddy; Mithun S Pawar; Debabrata Bhunia; Halmuthur M Sampath Kumar
Journal: ACS Med Chem Lett Date: 2015-12-10 Impact factor: 4.345

5. A molecular switch in mouse CD1d modulates natural killer T cell activation by α-galactosylsphingamides.

Authors: Jing Wang; Joren Guillaume; Jonas Janssens; Soumya G Remesh; Ge Ying; Aruna Bitra; Serge Van Calenbergh; Dirk M Zajonc
Journal: J Biol Chem Date: 2019-08-07 Impact factor: 5.157

6. Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Authors: Xiangming Li; Akira Kawamura; Chasity D Andrews; Jessica L Miller; Douglass Wu; Tiffany Tsao; Min Zhang; Deena Oren; Neal N Padte; Steven A Porcelli; Chi-Huey Wong; Stefan H I Kappe; David D Ho; Moriya Tsuji
Journal: J Immunol Date: 2015-08-07 Impact factor: 5.422

7. Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells.

Authors: Jordana G Coelho-Dos-Reis; Jing Huang; Tiffany Tsao; Felipe V Pereira; Ryota Funakoshi; Hiroko Nakajima; Haruo Sugiyama; Moriya Tsuji
Journal: Clin Immunol Date: 2016-04-27 Impact factor: 3.969