Literature DB >> 1671694

A relationship between microdosimetric spectra and cell survival for high-LET irradiation.

D E Charlton1, R Sephton.   

Abstract

A method of calculating cell survival from microdosimetric spectra for high-LET radiations and exponential cell survival is discussed. The basis of the calculation is that a cell nucleus receiving a specific dose D has a probability of survival of exp(-D/Do), where Do, the specific lethal dose, is assumed to be independent of cell size and shape. A relationship between specific lethal dose and mean lethal dose is derived. This approach gives the result that mean lethal dose is sensitive to both cell size and shape (cells with disc-shaped and spherical nuclei are treated) and therefore its uses as an indicator of cell sensitivity at high LET must be viewed with caution.

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Year:  1991        PMID： 1671694     DOI： 10.1080/09553009114550401

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  17 in total

1.  A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies.

Authors:  Prasad V S V Neti; Sonia M de Toledo; Venkatachalam Perumal; Edouard I Azzam; Roger W Howell
Journal:  Radiat Res       Date:  2004-06       Impact factor: 2.841

2.  Calculation of energy-deposition distributions and microdosimetric estimation of the biological effect of a 9C beam.

Authors:  Davide Mancusi; Lembit Sihver; Koji Niita; Qiang Li; Tatsuhiko Sato; Hiroshi Iwase; Yosuke Iwamoto; Norihiro Matsuda; Yukio Sakamoto; Hiroshi Nakashima
Journal:  Radiat Environ Biophys       Date:  2008-12-12       Impact factor: 1.925

3.  Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress.

Authors:  Manuela Buonanno; Sonia M de Toledo; Debkumar Pain; Edouard I Azzam
Journal:  Radiat Res       Date:  2011-02-14       Impact factor: 2.841

4.  Modeling multicellular response to nonuniform distributions of radioactivity: differences in cellular response to self-dose and cross-dose.

Authors:  Roger W Howell; Prasad V S V Neti
Journal:  Radiat Res       Date:  2005-02       Impact factor: 2.841

5.  Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells.

Authors:  Kurtis J Haro; Andrew C Scott; David A Scheinberg
Journal:  Blood       Date:  2012-07-24       Impact factor: 22.113

6.  In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria.

Authors:  Mohit R Jain; Min Li; Wei Chen; Tong Liu; Sonia M de Toledo; Badri N Pandey; Hong Li; Bernard M Rabin; Edouard I Azzam
Journal:  Curr Mol Pharmacol       Date:  2011-06       Impact factor: 3.339

7.  The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells.

Authors:  Narongchai Autsavapromporn; Sonia M de Toledo; John B Little; Jean-Paul Jay-Gerin; Andrew L Harris; Edouard I Azzam
Journal:  Radiat Res       Date:  2011-01-10       Impact factor: 2.841

8.  Participation of gap junction communication in potentially lethal damage repair and DNA damage in human fibroblasts exposed to low- or high-LET radiation.

Authors:  Narongchai Autsavapromporn; Masao Suzuki; Ianik Plante; Cuihua Liu; Yukio Uchihori; Tom K Hei; Edouard I Azzam; Takeshi Murakami
Journal:  Mutat Res       Date:  2013-07-15       Impact factor: 2.433

9.  Propagation distance of the alpha-particle-induced bystander effect: the role of nuclear traversal and gap junction communication.

Authors:  Sylvain Gaillard; David Pusset; Sonia M de Toledo; Michel Fromm; Edouard I Azzam
Journal:  Radiat Res       Date:  2009-05       Impact factor: 2.841

10.  Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations.

Authors:  Géraldine Gonon; Jean-Emmanuel Groetz; Sonia M de Toledo; Roger W Howell; Michel Fromm; Edouard I Azzam
Journal:  Radiat Res       Date:  2013-03-06       Impact factor: 2.841
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