Literature DB >> 23362147

Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Wei Zhang1, Jeffrey L Fortman, Jacob C Carlson, Jinyong Yan, Yi Liu, Fali Bai, Wenna Guan, Junyong Jia, Teatulohi Matainaho, David H Sherman, Shengying Li.   

Abstract

New hope for old bones: The plecomacrolide bafilomycin has been explored for decades as an anti-osteoporotic. However, its structural complexity has limited the synthesis of analogues. The cloning of the bafilomycin biosynthetic gene cluster from the environmental isolate Streptomyces lohii opens the door to the production of new analogues through bioengineering.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23362147      PMCID： PMC3771327          DOI： 10.1002/cbic.201200743

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  45 in total

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