Literature DB >> 16697640

Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.

David G Fatkins1, Andrew D Monnot, Weiping Zheng.   

Abstract

Peptides containing Nepsilon-thioacetyl-lysine and Nepsilon-acetyl-lysine were evaluated for their de(thio)acetylation catalyzed by human HDAC8 and SIRT1, two distinct protein deacetylases. Nepsilon-Thioacetyl-lysine was found to be a mimic of Nepsilon-acetyl-lysine for HDAC8-catalyzed reaction, but to confer inhibition against SIRT1. These results point to further diverse applications based on Nepsilon-thioacetyl-lysine.

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Year:  2006        PMID： 16697640     DOI： 10.1016/j.bmcl.2006.04.075

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  37 in total

1.  Thiosuccinyl peptides as Sirt5-specific inhibitors.

Authors:  Bin He; Jintang Du; Hening Lin
Journal:  J Am Chem Soc       Date:  2012-01-20       Impact factor: 15.419

2.  Mechanism-based affinity capture of sirtuins.

Authors:  Yana Cen; Jessica N Falco; Ping Xu; Dou Yeon Youn; Anthony A Sauve
Journal:  Org Biomol Chem       Date:  2010-12-24       Impact factor: 3.876

3.  A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK).

Authors:  Brett M Hirsch; Yujun Hao; Xiaopeng Li; Chrys Wesdemiotis; Zhenghe Wang; Weiping Zheng
Journal:  Bioorg Med Chem Lett       Date:  2011-06-22       Impact factor: 2.823

4.  Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme.

Authors:  Hai Xiong; Noah M Reynolds; Chenguang Fan; Markus Englert; Denton Hoyer; Scott J Miller; Dieter Söll
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-23       Impact factor: 15.336

Review 5.  Chemical probes for histone-modifying enzymes.

Authors:  Philip A Cole
Journal:  Nat Chem Biol       Date:  2008-10       Impact factor: 15.040

6.  Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

Authors:  Benjamin Maurer; Tobias Rumpf; Michael Scharfe; Diana A Stolfa; Martin L Schmitt; Wenjuan He; Eric Verdin; Wolfgang Sippl; Manfred Jung
Journal:  ACS Med Chem Lett       Date:  2012-10-06       Impact factor: 4.345

7.  A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Authors:  Hui Jing; Jing Hu; Bin He; Yashira L Negrón Abril; Jack Stupinski; Keren Weiser; Marisa Carbonaro; Ying-Ling Chiang; Teresa Southard; Paraskevi Giannakakou; Robert S Weiss; Hening Lin
Journal:  Cancer Cell       Date:  2016-03-14       Impact factor: 31.743

Review 8.  Sirtuin inhibitors as anticancer agents.

Authors:  Jing Hu; Hui Jing; Hening Lin
Journal:  Future Med Chem       Date:  2014-05       Impact factor: 3.808

9.  Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

Authors:  Lei Jin; Wentao Wei; Yaobin Jiang; Hao Peng; Jianhua Cai; Chen Mao; Han Dai; Wendy Choy; Jean E Bemis; Michael R Jirousek; Jill C Milne; Christoph H Westphal; Robert B Perni
Journal:  J Biol Chem       Date:  2009-06-16       Impact factor: 5.157

10.  [Dual genetic encoding of acetyl-lysine and non-deacetylatablethioacetyl-lysine mediated by flexizyme].

Authors:  Hai Xiong; Noah M Reynolds; Chenguang Fan; Markus Englert; Denton Hoyer; Scott J Miller; Dieter Söll
Journal:  Angew Chem Weinheim Bergstr Ger       Date:  2016-02-23
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