| Literature DB >> 21752644 |
Brett M Hirsch1, Yujun Hao, Xiaopeng Li, Chrys Wesdemiotis, Zhenghe Wang, Weiping Zheng.
Abstract
In the current study, we have identified N(ε)-thiocarbamoyl-lysine (TuAcK) as a general sirtuin inhibitory warhead which was shown to be able to confer potent sirtuin inhibition. This inhibition was also shown to be mechanism-based in that the TuAck residue was able to be processed by a sirtuin enzyme with the formation of a stalled S-alkylamidate intermediate.Entities:
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Year: 2011 PMID： 21752644 PMCID： PMC3146582 DOI： 10.1016/j.bmcl.2011.06.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823